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Overview of eukaryotic messenger RNA (mRNA) translation Translation of mRNA and ribosomal protein synthesis Initiation and elongation stages of translation involving RNA nucleobases, the ribosome, transfer RNA, and amino acids The three phases of translation: (1) in initiation, the small ribosomal subunit binds to the RNA strand and the initiator tRNA–amino acid complex binds to the start ...
M. Kilp, U. Knauer, A.V. Mikhalev, Monoids, Acts and Categories with Applications to Wreath Products and Graphs, De Gruyter Expositions in Mathematics vol. 29, Walter de Gruyter, 2000, ISBN 3-11-015248-7. Ronald V. Book and Friedrich Otto, String-rewriting Systems, Springer, 1993, ISBN 0-387-97965-4, chapter 7, "Algebraic Properties"
Translation is one of the key energy consumers in cells, hence it is strictly regulated. Numerous mechanisms have evolved that control and regulate translation in eukaryotes as well as prokaryotes. Regulation of translation can impact the global rate of protein synthesis which is closely coupled to the metabolic and proliferative state of a cell.
[2] [3] The mRNA sequence is determined by the sequence of genomic DNA. [4] In this context, the standard genetic code is referred to as translation table 1. [3] It can also be represented in a DNA codon table. The DNA codons in such tables occur on the sense DNA strand and are arranged in a 5 ′-to-3 ′ direction.
Translation initiation is sometimes described as three step process which initiation factors help to carry out. First, the tRNA carrying a methionine amino acid binds to the small subunit of ribosome, then binds to the mRNA , and finally joins together with the large subunit of ribosome.
Function f : [Z] 3 → [Z] 6 given by [k] 3 ↦ [3k] 6 is a semigroup homomorphism, since [3k ⋅ 3l] 6 = [9kl] 6 = [3kl] 6. However, f([1] 3) = [3] 6 ≠ [1] 6, so a monoid homomorphism is a semigroup homomorphism between monoids that maps the identity of the first monoid to the identity of the second monoid and the latter condition cannot be ...
Bacterial RNA polymerase is made up of four subunits and when a fifth subunit attaches, called the sigma factor (σ-factor), the polymerase can recognize specific binding sequences in the DNA, called promoters. [3] The binding of the σ-factor to the promoter is the first step in initiation.
Translation promotes transcription elongation and regulates transcription termination. Functional coupling between transcription and translation is caused by direct physical interactions between the ribosome and RNA polymerase ("expressome complex"), ribosome-dependent changes to nascent mRNA secondary structure which affect RNA polymerase activity (e.g. "attenuation"), and ribosome-dependent ...