Search results
Results from the WOW.Com Content Network
Typical purpura on lower leg More severe case of HSP on child's foot, leg, and arm. Purpura, arthritis, and abdominal pain are known as the "classic triad" of Henoch–Schönlein purpura. [5] Purpura occur in all cases, joint pains and arthritis in 80%, and abdominal pain in 62%.
Nonthrombocytopenic purpura is a type of purpura (red or purple skin discoloration) not associated with thrombocytopenia. [1] Nonthrombocytopenic purpura has been reported after smoking mentholated cigarettes. [2] Examples/causes include: Henoch–Schönlein purpura [3] Hereditary hemorrhagic telangiectasia [4] Congenital cytomegalovirus [1 ...
In cases where a cause can be determined, medications and infectious pathogens are most common in adults, while IgA vasculitis (Henoch–Schönlein purpura) frequently affects children. [6] Other etiologies include autoimmune conditions and malignancies, usually hematologic (related to the blood). [5] [6]
Purpura (/ ˈ p ɜːr p jʊər ə / [1]) is a condition of red or purple discolored spots on the skin that do not blanch on applying pressure. The spots are caused by bleeding underneath the skin secondary to platelet disorders, vascular disorders, coagulation disorders, or other causes. [ 2 ]
Inflammation-induced damage to the skin's blood vessels causes palpable purpura. Palpable purpura is the clinical manifestation of leukocytoclastic vasculitis, which can be idiopathic or linked to sepsis, reactions to drugs, connective tissue diseases, cryoglobulinemia, hepatitis C or B infection, or underlying cancers
The more aggressive forms of disease require treatment with chemotherapy, radiotherapy, immunotherapy and—in some cases—a bone marrow transplant. The use of rituximab has been established for the treatment of B-cell–derived hematologic malignancies, including follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). [7]
Acute lymphoblastic leukemia represents approximately 20% of adults and 80% of childhood leukemias, making it the most common childhood cancer. [5] Although 80 to 90% of children will have a long term complete response with treatment, [45]: 1527 it remains the leading cause of cancer-related deaths among children. [82] 85% of cases are of B ...
Immune complex glomerulonephritis, as seen in Henoch-Schönlein purpura; this is an example of IgA involvement in a nephropathy. The reaction can take hours, days, or even weeks to develop, depending on whether or not there is immunological memory of the precipitating antigen. Typically, clinical features emerge a week following initial antigen ...