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Pyrimidine (C 4 H 4 N 2; / p ɪ ˈ r ɪ. m ɪ ˌ d iː n, p aɪ ˈ r ɪ. m ɪ ˌ d iː n /) is an aromatic, heterocyclic, organic compound similar to pyridine (C 5 H 5 N). [3] One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has nitrogen atoms at positions 1 and 3 in the ring.
Left: The structure of pyrimidine with the locants for ring atoms marked. Right : 5-Fluorouracil , a fluoropyrimidine formally named as 5-fluoro-1 H ,3 H -pyrimidine-2,4-dione Fluoropyrimidines are a general class organic compounds in which the substituent (s) around a pyrimidine ring include at least one fluorine atom.
Dihydrouridine (abbreviated as D, [1] DHU, or UH 2) is a pyrimidine nucleoside which is the result of adding two hydrogen atoms to a uridine, making it a fully saturated pyrimidine ring with no remaining double bonds.
Uridine (symbol U or Urd) is a glycosylated pyrimidine analog containing uracil attached to a ribose ring (or more specifically, a ribofuranose) via a β-N 1-glycosidic bond.The analog is one of the five standard nucleosides which make up nucleic acids, the others being adenosine, thymidine, cytidine and guanosine.
It is an aromatic heterocycle with a bicyclic structure consisting of two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring. It is a light yellow crystalline solid that is soluble in water. Also known as 1,3-diazanaphthalene, quinazoline received its name from being an aza derivative of quinoline. Though the parent ...
The region is rich with pyrimidine nucleotides, especially uracil, and is usually 15–20 base pairs long, located about 5–40 base pairs before the 3' end of the intron to be spliced. [ 1 ] A number of protein factors bind to or associate with the polypyrimidine tract, including the spliceosome component U2AF and the polypyrimidine tract ...
5-Formylcytosine (5fC) is a pyrimidine nitrogen base derived from cytosine.In the context of nucleic acid chemistry and biology, it is regarded as an epigenetic marker. Discovered in 2011 in mammalian embryonic stem cells by Thomas Carell's research group [1] the modified nucleoside was more recently confirmed to be relevant both as an intermediate in the active demethylation pathway and as a ...
In enzymology, a ribosylpyrimidine nucleosidase (EC 3.2.2.8) is an enzyme that catalyzes the chemical reaction. a pyrimidine nucleoside + H 2 O D-ribose + a pyrimidine base. Thus, the two substrates of this enzyme are pyrimidine nucleoside and H 2 O, whereas its two products are D-ribose and pyrimidine base.