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  2. Aficamten - Wikipedia

    en.wikipedia.org/wiki/Aficamten

    Aficamten (CK-274) is a cardiac myosin inhibitor [1] developed by Cytokinetics for the treatment of obstructive hypertrophic cardiomyopathy. [ 2 ] [ 3 ] [ 4 ] References

  3. Hypertrophic cardiomyopathy - Wikipedia

    en.wikipedia.org/wiki/Hypertrophic_cardiomyopathy

    Mavacamten was shown to reduce left ventricular outflow tract gradient (a measure of obstruction) and improve symptoms in patients with obstructive hypertrophic cardiomyopathy, and was approved for medical use in the United States in April 2022 [52] Aficamten, which has a shorter half life compared with mavacamten, achieves steady state within ...

  4. Cytokinetics - Wikipedia

    en.wikipedia.org/wiki/Cytokinetics

    In 2013, Cytokinetics finalized a licensing and discovery deal with Astellas to research treatment for muscle weakness and fatigue. [ 8 ] In July 2020, Ji Xing Pharmaceuticals signed a financing deal with Cytokinetics, which included the rights to commercialize the drug designed to treat hypertrophic cardiomyopathies, aficamten , in China and ...

  5. Cytokinetics Presents New Data Related to the Safety ... - AOL

    lite.aol.com/tech/story/0022/20240901/9223623.htm

    Patients with obstructive HCM who received at least one dose of aficamten or placebo were included in this analysis. A total of 283 patients received at least one dose of aficamten and 153 patients received at least one dose of placebo. Overall, treatment with aficamten was well-tolerated with an adverse event profile similar to placebo. Across ...

  6. Alnylam gives up on expanded use of heart-disease drug in US ...

    www.aol.com/news/us-fda-declines-approval...

    The regulator, in its so-called complete response letter, said the drug patisiran did not meaningfully improve the condition of patients with heart muscle issues or cardiomyopathy caused by ATTR ...

  7. Here’s the Deal With Veozah, the New FDA-Approved Medication ...

    www.aol.com/deal-veozah-fda-approved-medication...

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  8. MYK-224 - Wikipedia

    en.wikipedia.org/wiki/MYK-224

    MYK-224 is a small-molecule cardiac myosin inhibitor developed by Bristol Myers Squibb for hypertrophic cardiomyopathy. [1] [2] [3] References

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