Search results
Results from the WOW.Com Content Network
Most individuals with G6PD deficiency are asymptomatic.When it induces hemolysis, it is usually is short-lived. [5]Most people who develop symptoms are male, due to the X-linked pattern of inheritance, but female carriers can be affected due to unfavorable lyonization or skewed X-inactivation, where random inactivation of an X-chromosome in certain cells creates a population of G6PD-deficient ...
Genetically induced chronic low-level methemoglobinemia may be treated with oral methylene blue daily. Also, vitamin C can occasionally reduce cyanosis associated with chronic methemoglobinemia, and may be helpful in settings in which methylene blue is unavailable or contraindicated (e.g., in an individual with G6PD deficiency). [22]
If drug-induced nonautoimmune hemolytic anemia occurs secondarily to drug induced methemoglobinemia, methylene blue can be used as a first-line therapy. However methylene blue should be avoided in those with a concomitant G6PD deficiency as methylene blue may cause further oxidative hemolysis.
G6PD deficiency by itself is usually asymptomatic, but when combined with external stress such as an infection, fava beans, or oxidative drugs like primaquine. [25] Primaquine and tafenoquine can pass through the placenta, causing hemolytic anemia in utero if the fetus has G6PD deficiency. [26]
G6PD reduces NADP + to NADPH while oxidizing glucose-6-phosphate. [2] Glucose-6-phosphate dehydrogenase is also an enzyme in the Entner–Doudoroff pathway, a type of glycolysis. Clinically, an X-linked genetic deficiency of G6PD makes a human prone to non-immune hemolytic anemia. [3]
Cuban authorities struggled to return power to the island on Thursday morning after Hurricane Rafael knocked out the country`s electrical grid, leaving 10 million people in the dark.
AOL Mail welcomes Verizon customers to our safe and delightful email experience!
A special edition of "20/20" airing Dec. 19 at 10 p.m. ET on ABC looks at the murder of UnitedHealthcare CEO Brian Thompson and the manhunt that led to the arrest of Luigi Mangione, who went from ...