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In analytical chemistry, the detection limit, lower limit of detection, also termed LOD for limit of detection or analytical sensitivity (not to be confused with statistical sensitivity), is the lowest quantity of a substance that can be distinguished from the absence of that substance (a blank value) with a stated confidence level (generally 99%).
In the empirical sciences, the so-called three-sigma rule of thumb (or 3 σ rule) expresses a conventional heuristic that nearly all values are taken to lie within three standard deviations of the mean, and thus it is empirically useful to treat 99.7% probability as near certainty.
A calibration curve plot showing limit of detection (LOD), limit of quantification (LOQ), dynamic range, and limit of linearity (LOL).. In analytical chemistry, a calibration curve, also known as a standard curve, is a general method for determining the concentration of a substance in an unknown sample by comparing the unknown to a set of standard samples of known concentration. [1]
About 68% of values drawn from a normal distribution are within one standard deviation σ from the mean; about 95% of the values lie within two standard deviations; and about 99.7% are within three standard deviations. [8] This fact is known as the 68–95–99.7 (empirical) rule, or the 3-sigma rule.
The sample extrema can be used for a simple normality test, specifically of kurtosis: one computes the t-statistic of the sample maximum and minimum (subtracts sample mean and divides by the sample standard deviation), and if they are unusually large for the sample size (as per the three sigma rule and table therein, or more precisely a Student ...
The IQR of a set of values is calculated as the difference between the upper and lower quartiles, Q 3 and Q 1. Each quartile is a median [8] calculated as follows. Given an even 2n or odd 2n+1 number of values first quartile Q 1 = median of the n smallest values third quartile Q 3 = median of the n largest values [8]
The median absolute deviation is a measure of statistical dispersion. Moreover, the MAD is a robust statistic , being more resilient to outliers in a data set than the standard deviation . In the standard deviation, the distances from the mean are squared, so large deviations are weighted more heavily, and thus outliers can heavily influence it.
Relative probabilities in a normal distribution. In the case of normally distributed data, the three sigma rule means that roughly 1 in 22 observations will differ by twice the standard deviation or more from the mean, and 1 in 370 will deviate by three times the standard deviation. [6]