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A transcription factor is a protein that binds to specific DNA sequences (enhancer or promoter), either alone or with other proteins in a complex, to control the rate of transcription of genetic information from DNA to messenger RNA by promoting (serving as an activator) or blocking (serving as a repressor) the recruitment of RNA polymerase.
Other transcription factors differentially regulate the expression of various genes by binding to enhancer regions of DNA adjacent to regulated genes. These transcription factors are critical to making sure that genes are expressed in the right cell at the right time and in the right amount, depending on the changing requirements of the organism.
Transcription factor TF II A is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA. [1] TF II A is one of several general (basal) transcription factors ( GTFs ) that are required for all transcription events that use RNA polymerase II.
66464 Ensembl ENSG00000120656 ENSMUSG00000028899 UniProt Q16514 Q8VE65 RefSeq (mRNA) NM_001135218 NM_005644 NM_025579 RefSeq (protein) NP_001128690 NP_005635 NP_079855 Location (UCSC) Chr 1: 28.59 – 28.65 Mb Chr 4: 132 – 132.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene ...
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals.
TFIID is composed of the TATA binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription ...
TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation.
Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor.