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Eating a diet devoid of any animal products, fortified plant-based products, or supplements is one of the ways you can deplete your body of B12, but there are other reasons your body may not get ...
Over time, a deficiency of B12 can cause problems with balance, confusion, depression, poor memory and possibly dementia, and it can even cause permanent damage to the nervous system, Somers says.
A diagnosis of vitamin B 12 deficiency is determined by blood levels lower than 200 or 250 picograms per ml (148 or 185 picomoles per liter). Measurement of blood methylmalonic acid (MMA), a vitamin B 12-associated metabolite, is a commonly used biomarker. [2] Deficiency is often suspected first, as diagnosis usually requires several tests.
Reduced serum levels of vitamin B 12 occur in up to 30% of people taking long-term anti-diabetic metformin. [105] [106] Deficiency does not develop if dietary intake of vitamin B 12 is adequate or prophylactic B 12 supplementation is given. If the deficiency is detected, metformin can be continued while the deficiency is corrected with B 12 ...
Vitamin B 12 serum levels are used to detect its deficiency, but do not distinguish its causes. Vitamin B 12 levels can be falsely high or low and data for sensitivity and specificity vary widely. Normal serum levels may be found in cases of deficiency where myeloproliferative disorders , liver disease , transcobalamin II , or small intestinal ...
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