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The Sinclair Method, as the protocol has been named, was the subject of a large body of laboratory studies [7] and used in over 90 clinical trials around the world. [8] [9] The Sinclair Method, which is simply taking an opioid antagonist before drinking, has been found to be successful in about 80% of Alcohol Use Disorder (AUD) sufferers.
Acamprosate may work better than naltrexone for eliminating alcohol abuse, while naltrexone may decrease the desire for alcohol to a greater extent. [26] A method pioneered by scientist John David Sinclair (dubbed commercially the “Sinclair Method”) advocates for “pharmacological extinction” of problem drinking behavior by administering ...
One Little Pill is a documentary film about the Sinclair method of treating alcohol abuse. [2] The film follows the lives of several people who have suffered from alcoholism, and have been helped by the treatment. Perspectives from scientists, treatment centers, doctors, and a legal prosecutor are also presented.
Christian is an advocate of The Sinclair Method (TSM), a medication-based method for treating alcohol dependence. TSM involves the targeted use of Naltrexone. She credits TSM with saving her life in 2009. [46]
Another common method of alcoholism prevention is taxation of alcohol products – increasing price of alcohol by 10% is linked with reduction of consumption of up to 10%. [ 138 ] Credible, evidence-based educational campaigns in the mass media about the consequences of alcohol misuse have been recommended.
In 1969, the government owned Alko Labs - currently the National Public Health and Welfare Institute, Helsinki - recruited Dr. David Sinclair from the University of Oregon after his publications on the Alcohol Deprivation Effect [1] with the first human trials using naltrexone and nalmefene starting in the mid 1990s.
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