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The androgen backdoor pathways occur without the involvement of testosterone (T) and/or androstenedione (A4), which are part of the conventional, canonical (classic) [30] [31] [11] androgenic pathway. [15] In the canonical pathways of androgen biosynthesis, DHT is synthesized from T via 5α-reduction, so that 5α-reduction of T, a C
Schematic diagram of the androgen biosynthesis via the canonical, backdoor, and 11-oxyback door pathways ... Added the 11-oxy backdoor pathway is also important in ...
English: Will update with all enzyme names once diagram is checked for accuracy. Date: 5 February 2021: Source: Own work: Author: ... The androgen backdoor pathway ...
The androgen backdoor pathway (red arrows) roundabout testosterone embedded in within conventional androgen synthesis that lead to 5α-dihydrotestosterone through testosterone [27] [28] [29] CAH is a genetic disorder characterized by impaired production of cortisol in the adrenal glands. [1] [4] Production of cortisol begins at week 8 of fetal ...
As with the conventional pathway of DHT synthesis, the backdoor pathway similarly requires 5α-reductase. [63] Whereas 5α-reduction is the last transformation in the classical androgen pathway, it is the first step in the backdoor pathway. [17]
The androgen backdoor pathway (red arrows) roundabout testosterone embedded in within conventional androgen synthesis that lead to 5α-dihydrotestosterone through testosterone. [7] [8] [9] 5α-Pregnan-17α-ol-3,20-dione (17-OH-DHP) is a progestogen, i.e., it binds to the progesterone receptors.
The activity of this enzyme towards 3α-diol is important not only in the conventional pathways of androgen biosynthesis, but also in the androgen backdoor patthway. [ 21 ] [ 22 ] [ 23 ] [ 7 ] An important emzyme activity in humans is the transformation of the one of the most potent natural androgens, 5α-dihydrotestosterone into 3α-diol, a ...
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