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The cleavage, followed by the association of the two fragments, is necessary for KMT2A to be fully active. Like many other methyltransferases, the KMT2 family members exist in multisubunit nuclear complexes (human COMPASS), where other subunits also mediate the enzymatic activity. [17]
It is part of a family of six Set1-like H3K4 methyltransferases that also contains KMT2A (or MLL1), KMT2B (or MLL2), KMT2C (or MLL3), KMT2F (or SET1A), and KMT2G (or SET1B). KMT2D is a large protein over 5,500 amino acids in size and is widely expressed in adult tissues. [ 6 ]
58508 231051 Ensembl ENSG00000055609 n/a UniProt Q8NEZ4 Q8BRH4 RefSeq (mRNA) NM_021230 NM_170606 NM_001081383 NM_177283 RefSeq (protein) NP_733751 n/a Location (UCSC) Chr 7: 152.13 – 152.44 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Lysine N-methyltransferase 2C (KMT2C) also known as myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3) is an enzyme that in humans is ...
The PHD finger occurs in proteins such as the transcriptional co-activators p300 and CBP, Polycomb-like protein (Pcl), Trithorax-group proteins like ASH1L, ASH2L and MLL, the autoimmune regulator (AIRE), Mi-2 complex (part of histone deacetylase complex), the co-repressor TIF1, the JARID1-family of demethylases and many more.
Histone methyltransferases (HMT) are histone-modifying enzymes (e.g., histone-lysine N-methyltransferases and histone-arginine N-methyltransferases), that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins.
Amna was born in Washington, Virginia in the United States.She is the daughter of Khaled Al Qubaisi, former [2] CEO of Real Estate and Infrastructure Investment platform at Mubadala Investment Company [3] and also a racing driver who was the first Emirati to compete at the 24 Hours of Le Mans race in France, claiming two class podiums. [4]
In the 2021 Formula 4 UAE Championship, Hamda secured a further three wins, one pole position, and six podiums, to clinch fourth place in the standings once more. [5] In her main campaign, she took part in the Italian F4 Championship. [6]
The Musk family is a prominent family with roots in South Africa, Canada, England, and the United States, whose most famous member is billionaire Elon Musk. It also includes his parents Maye Musk , a model and author, and Errol Musk , a mine-owner, businessman and politician; siblings Kimbal Musk and Tosca Musk , and cousin Lyndon Rive .