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Alzheimer's financial burden on society is large, with an estimated global annual cost of US$1 trillion. [14] It is ranked as the seventh leading cause of death worldwide. [30] Given the widespread impacts of Alzheimer's disease, both basic-science and health funders in many countries support Alzheimer's research at large scales.
The leading causes of death were fairly consistent for years until the COVID-19 pandemic hit. Once the pandemic started, the virus was the third leading cause of death in 2020 and the years ...
People aged 75 and over accounted for the majority (72%) of the burden due to dementia. [1] It was the leading cause of death for women and third leading cause of death for men. [2] [4] There is a sex bias, as women have higher mortality rates, morbidity and burden of dementia than men. [1] [2] In 2018, 61% of people with dementia were women. [2]
The cause of this selective cell death is unknown. Notably, alpha-synuclein - ubiquitin complexes and aggregates are observed to accumulate in Lewy bodies within affected neurons. It is thought that defects in protein transport machinery and regulation, such as RAB1 , may play a role in this disease mechanism. [ 24 ]
The exact cause of Alzheimer’s disease has long evaded scientists, but experts typically suggest there are likely several factors (like genetics, environment, and lifestyle) that contribute to ...
Meanwhile, chronic liver disease and cirrhosis were the 11th leading cause of death in 2019 but had climbed to the ninth slot by 2023, with the mortality rate rising by 15% in that span of time ...
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