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Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]
Causes Narcolepsy , idiopathic hypersomnia , circadian rhythm sleep disorder , sleep apnea , others Excessive daytime sleepiness ( EDS ) is characterized by persistent sleepiness and often a general lack of energy, even during the day after apparently adequate or even prolonged nighttime sleep.
Narcolepsy: A chronic neurological disorder (or dyssomnia), which is caused by the brain's inability to control sleep and wakefulness. [94] Idiopathic hypersomnia: A chronic neurological disease similar to narcolepsy, in which there is an increased amount of fatigue and sleep during the day. Patients who have idiopathic hypersomnia cannot ...
Axsome (AXSM) accelerates the development plan for AXS-12 to treat narcolepsy after a Breakthrough Therapy meeting with the FDA authorities. Stock dips.
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Patients with sleeping disorders following TBI specifically develop insomnia, sleep apnea, narcolepsy, periodic limb movement disorder and hypersomnia. [ 1 ] [ 3 ] [ 4 ] Furthermore, circadian sleep-wake disorders can occur after TBI.
Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...
Genes associated with narcolepsy modulate the expression of the specific T cell receptor recognition involved in reaction to these antigens, suggesting H1N1 infection is a cause of narcolepsy in genetically susceptible individuals. T-cells stimulated by Pandemrix were cross-reactive by molecular mimicry with the same part of the hypocretin peptide.
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