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Replacement: methods which avoid the use of animals in research; Reduction: use of methods that enable researchers to minimise the number of animals necessary to obtain reliable and useful information. Refinement: use of methods that alleviate or minimize potential pain, suffering, distress, or lasting harm and improve welfare for the animals used.
Finnish Center for Alternative Methods (FICAM), since 2008 [115] FRANCOPA is the French platform dedicated to development, validation, and dissemination of alternative methods in animal testing. It was created on November 16, 2007. [116] The Italian Centro 3R was created in 2017. It is an interuniversity center dedicated to the promotion of the ...
The dominant research method is the randomised controlled trial. Qualitative research is based in the paradigm of phenomenology , grounded theory , ethnography and others, and examines the experience of those receiving or delivering the nursing care, focusing, in particular, on the meaning that it holds for the individual.
Many point-of-care test systems are realized as easy-to-use membrane-based test strips, often enclosed by a plastic test cassette. [2] This concept often is realized in test systems for detecting pathogens, the most common being COVID-19 rapid tests. Very recently such test systems for rheumatology diagnostics have been developed, too. [12]
A test method is a method for a test in science or engineering, such as a physical test, chemical test, or statistical test. It is a definitive procedure that produces a test result. [ 1 ] In order to ensure accurate and relevant test results, a test method should be "explicit, unambiguous, and experimentally feasible.", [ 2 ] as well as ...
A type of research study that tests how well new medical approaches work in people. These studies test new methods of screening, prevention, diagnosis, or treatment of a disease. Also called a clinical trial. (NCI) A clinical trial is a research study to answer specific questions about vaccines or new therapies or new ways of using known ...
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The statement that is being tested against the null hypothesis is the alternative hypothesis. [2] Alternative hypothesis is often denoted as H a or H 1. In statistical hypothesis testing, to prove the alternative hypothesis is true, it should be shown that the data is contradictory to the null hypothesis. Namely, there is sufficient evidence ...