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Generic companies incur fewer costs in creating generic drugs—only the cost of manufacturing, without the costs of drug discovery and drug development—and are therefore able to maintain profitability at a lower price. [19] [20] [21] The prices are often low enough for users in less-prosperous countries to afford them.
Diltiazem, sold under the brand name Cardizem among others, is a nondihydropyridine calcium channel blocker medication used to treat high blood pressure, angina, and certain heart arrhythmias. [9] It may also be used in hyperthyroidism if beta blockers cannot be used. [ 9 ]
1,3-thiazepine 1,4-thiazepine Diltiazem. 1,4-thiazepine is the seven membered ring in the middle. Thiazepines are substituted thiepins, with a nitrogen replacing a carbon in the seven-membered heterocyclic compound. [1] Depending on the location of the nitrogen, one distinguishes 1,3-thiazepine and 1,4-thiazepine. [1]
Benzothiadiazine, the parent structure of this class of molecules. Thiazide (/ ˈ θ aɪ ə z aɪ d /) refers to both a class of sulfur-containing organic molecules [1] and a class of diuretics based on the chemical structure of benzothiadiazine. [2]
Diazoxide is used as a vasodilator in the treatment of acute hypertension or malignant hypertension. [7]Diazoxide also inhibits the secretion of insulin by opening ATP-sensitive potassium channel of beta cells of the pancreas; thus, it is used to counter hypoglycemia in disease states such as insulinoma (a tumor producing insulin) [8] or congenital hyperinsulinism.
Imipramine, sold under the brand name Tofranil, among others, is a tricyclic antidepressant (TCA) mainly used in the treatment of depression.It is also effective in treating anxiety and panic disorder.
Ranolazine, sold under the brand name Ranexa among others, is a medication used to treat heart related chest pain. [5] Typically it is used together with other medications when those are insufficient.
Gabapentin is recommended for use in focal seizures and neuropathic pain. [7] [10] Gabapentin is prescribed off-label in the US and the UK, [22] [23] for example, for the treatment of non-neuropathic pain, [22] anxiety disorders, sleep problems and bipolar disorder. [24]