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  2. Somatostatin inhibitor - Wikipedia

    en.wikipedia.org/wiki/Somatostatin_inhibitor

    Hepatic insulin sensitizing substance (HISS), a hormone, will be secreted by the liver which stimulates skeletal muscle glucose uptake when responding to insulin. [39] This action makes up around 56% of total insulin action. [39] Hemorrhage was shown to cause insulin resistance by this type of HISS-dependent insulin resistance (HDIR). [40]

  3. Somatostatin - Wikipedia

    en.wikipedia.org/wiki/Somatostatin

    Somatostatin is secreted by delta cells at several locations in the digestive system, namely the pyloric antrum, the duodenum and the pancreatic islets. [14]Somatostatin released in the pyloric antrum travels via the portal venous system to the heart, then enters the systemic circulation to reach the locations where it will exert its inhibitory effects.

  4. Somatostatin receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Somatostatin_receptor...

    Cyclosomatostatin is one such compound. Contrary to previously discussed compounds, cyclosomatostatin does not contain a radionuclide. It is a non-selective somatostatin receptor antagonist, [35] inhibiting the effects of somatostatin on target cells in the gastrointestinal (GI) tract, pancreas, hypothalamus, and central nervous system (CNS). [2]

  5. Octreotide - Wikipedia

    en.wikipedia.org/wiki/Octreotide

    Octreotide, sold under the brand name Sandostatin among others, is an octapeptide that mimics natural somatostatin pharmacologically, though it is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone. It was first synthesized in 1979 and binds predominantly to the somatostatin receptors SSTR2 and SSTR5. [5]

  6. Somatostatin receptor 2 - Wikipedia

    en.wikipedia.org/wiki/Somatostatin_receptor_2

    The somatostatin hormone itself can negatively affect the uptake of hormones in the body and may play a role in some hormonal conditions. Somatostatin 2 receptors have been found in concentration on the surface of tumor cells, particularly those associated with the neuroendocrine system where the overexpression of somatostatin can lead to many complications [22] [23] Due to this, these ...

  7. Latent autoimmune diabetes in adults - Wikipedia

    en.wikipedia.org/wiki/Latent_autoimmune_diabetes...

    A fasting blood sugar level of ≥ 7.0 mmol / L (126 mg/dL) is used in the general diagnosis of diabetes. [17] There are no clear guidelines for the diagnosis of LADA, but the criteria often used are that the patient should develop the disease in adulthood, not need insulin treatment for the first 6 months after diagnosis and have autoantibodies in the blood.

  8. Somatostatin receptor 4 - Wikipedia

    en.wikipedia.org/wiki/Somatostatin_receptor_4

    20608 Ensembl ENSG00000132671 ENSMUSG00000037014 UniProt P31391 P49660 RefSeq (mRNA) NM_001052 NM_009219 RefSeq (protein) NP_001043 NP_033245 Location (UCSC) Chr 20: 23.04 – 23.04 Mb Chr 2: 148.24 – 148.24 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene. Function Somatostatin acts at many sites ...

  9. Randle cycle - Wikipedia

    en.wikipedia.org/wiki/Randle_cycle

    The Randle cycle, also known as the glucose fatty-acid cycle, is a metabolic process involving the cross inhibition of glucose and fatty acids for substrates. [1] It is theorized to play a role in explaining type 2 diabetes and insulin resistance.