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Alchemists have the ability, with the help of patterns called transmutation circles, to create almost anything they desire. However, when they do so, they must provide something of equal value in accordance with the Law of Equivalent Exchange. The only things alchemists are forbidden from transmuting are humans and gold.
After Ross' departure, Edward finds a damaged transmutation circle along with a group of Ishvalan refugees, who reveal that it was Scar who killed Winry's parents while they gave medical aid to the Ishvalan during the civil war. 11: July 22, 2005 [32] 978-4-7575-1496-6: January 16, 2007 [33] 978-1-4215-0838-2
Some alchemists also circulated steps for the creation of practical medicines and substances, that have little to do with the magnum opus. The cryptic and often symbolic language used to describe both adds to the confusion, but it's clear that there is no single standard step-by-step recipe given for the creation of the philosopher's stone.
The squared circle: an alchemical symbol (17th century) illustrating the interplay of the four elements of matter symbolising the philosopher's stone. Antimony ♁ (in Newton), also ; Arsenic 🜺 Bismuth ♆ (in Newton), 🜘 (in Bergman) Cobalt (approximately 🜶) (in Bergman) Manganese (in Bergman)
Izumi could thereafter perform alchemy without a transmutation circle, because in the failed transmutation she saw the Truth (真理, Shinri). Izumi attracts the attention of the State Military for having survived the failed human transmutation. As she and her husband travel around Amestris in order to avoid the military, they eventually meet ...
It gave Hohenheim his current name and taught him the basics of alchemy. Homunculus promised to make the King of Xerxes immortal, and told the king to make a gigantic transmutation circle. At the appointed time, Hohenheim stood at the center of the circle with Homunculus, and the whole country, including the king became a sacrifice.
Upon slightly conciliating with a gradually reformed Lust, Scar uses the last of his strength to complete and activate the transmutation circle around the city, dying as the transmutation took place, and the Philosopher's Stone is completed - within Alphonse, saving his life and killing several groups of soldiers attacking Lior. [28]
Edward lost his left leg while meeting the metaphysical being known as Truth (真理, Shinri), gaining great knowledge as well as the prodigious ability to perform transmutations just by clapping his hands together without the need of a Transmutation Circle. [20]