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Dibenzofuran is a heterocyclic organic compound with the chemical structure shown at right. It is an aromatic compound that has two benzene rings fused to a central furan ring. All the numbered carbon atoms have a hydrogen atom bonded to each of them. It is a volatile white solid that is soluble in nonpolar organic solvents.
Polychlorinated dibenzofurans with chlorines at least in positions 2,3,7 and 8 are much more toxic than the parent compound dibenzofuran, with properties and chemical structures similar to polychlorinated dibenzodioxins. These groups together are often inaccurately called dioxins.
2,3,7,8-Tetrachlorodibenzofuran (TCDF) is a polychlorinated dibenzofuran with a chemical formula of C 12 H 4 Cl 4 O. TCDF is part of the chlorinated benzofuran (CDF) family that contains between 1 and 8 chlorine atoms attached to the parent dibenzofuran ring system. The CDF family includes 135 compounds, of which only a few have been studied.
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Dibenzofuran, an analog with a second fused benzene ring. Furan, an analog without the fused benzene ring. Indole, an analog with a nitrogen instead of the oxygen atom. Benzothiophene, an analog with a sulfur instead of the oxygen atom. Isobenzofuran, the isomer with oxygen in the adjacent position. Aurone; Thunberginol F
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TCDD and dioxin-like compounds act via a specific receptor present in all cells: the aryl hydrocarbon (AH) receptor. [6] [7] [8] This receptor is a transcription factor which is involved in the expression of genes; it has been shown that high doses of TCDD either increase or decrease the expression of several hundred genes in rats. [9]
Diclofenac, sold under the brand name Voltaren among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. [6] [9] It can be taken orally (swallowed by mouth), inserted rectally as a suppository, injected intramuscularly, injected intravenously, applied to the skin topically, or through eye drops.