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"Indiana University Department of Medicine Clinical Pharmacology Drug Interactions Flockhart Table ™". "INHIBITORS, INDUCERS AND SUBSTRATES OF CYTOCHROME P450 ISOZYMES". "The Life Raft Group: Long List of Inhibitors and Inducers of CYP3A4 and CYP2D6". "DRUGBANK Online: Cytochrome P-450 Enzyme Inhibitors".
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. The first published report on grapefruit drug interactions was in 1991 in the Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine", and was the first reported food-drug interaction clinically. The effects of grapefruit last ...
Flockhart DA (2008-09-04). "Human Cytochrome P450 (CYP) Allele Nomenclature Committee". Karolinska Institutet; Sigaroudi A, Vollbrecht H (2019). "pharmacokinetic interaction table". Sigaroudi & Vollbrecht. Sim SC (2007). "Cytochrome P450 drug interaction table". Indiana University-Purdue University Indianapolis
1559 72303 Ensembl ENSG00000138109 ENSMUSG00000067231 UniProt P11712 n/a RefSeq (mRNA) NM_000771 NM_028191 RefSeq (protein) NP_000762 n/a Location (UCSC) Chr 10: 94.94 – 94.99 Mb Chr 19: 39.05 – 39.08 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome P450 family 2 subfamily C member 9 (abbreviated CYP2C9) is an enzyme protein. The enzyme is involved in the metabolism, by ...
1555 13088 Ensembl ENSG00000197408 ENSMUSG00000030483 UniProt P20813 P12791 RefSeq (mRNA) NM_000767 NM_009999 RefSeq (protein) NP_000758 n/a Location (UCSC) Chr 19: 40.99 – 41.02 Mb Chr 7: 25.6 – 25.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene. CYP2B6 is a member of the cytochrome P450 group of ...
Following is a table of selected substrates, inducers and inhibitors of CYP1A2. Inhibitors of CYP1A2 can be classified by their potency , such as: Strong inhibitor being one that causes at least a 5-fold increase in the plasma AUC values of sensitive substrates metabolized through CYP1A2, or more than 80% decrease in clearance thereof.
13106 Ensembl ENSG00000130649 ENSMUSG00000025479 UniProt P05181 Q05421 RefSeq (mRNA) NM_000773 NM_021282 RefSeq (protein) NP_000764 NP_067257 Location (UCSC) Chr 10: 133.52 – 133.56 Mb Chr 7: 140.34 – 140.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system ...
1557 n/a Ensembl ENSG00000165841 n/a UniProt P33261 n/a RefSeq (mRNA) NM_000769 n/a RefSeq (protein) NP_000760 n/a Location (UCSC) Chr 10: 94.76 – 94.86 Mb n/a PubMed search n/a Wikidata View/Edit Human Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme protein. It is a member of the CYP2C subfamily of the cytochrome P450 mixed-function oxidase system. This subfamily includes enzymes ...