Search results
Results from the WOW.Com Content Network
Unique among the ALDH1 isozymes, ALDH1A1 is known to possess esterase activity in biochemical studies, [11] although it is unclear whether this is functionally relevant living tissues. ALDH1A1 is expressed predominantly in metabolic tissues, including the liver, gastrointestinal tract, thyroid, pituitary gland, and adipose tissues. [12]
Aldehyde dehydrogenase is a polymorphic enzyme [3] responsible for the oxidation of aldehydes to carboxylic acids. [3] There are three different classes of these enzymes in mammals: class 1 (low K m, cytosolic), class 2 (low K m, mitochondrial), and class 3 (high K m, such as those expressed in tumors, stomach, and cornea).
Furthermore, the preceding sequence Gln-Gly-Gln-Cys is conserved in both isozymes for both human and horse, which is consistent with Cys-302 being crucial to catalytic function. [ 2 ] As discovered by site-directed mutagenesis , glutamate -268 is a key component of liver acetaldehyde dehydrogenase and is also critical to catalytic activity.
In biochemistry, isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. Isozymes usually have different kinetic parameters (e.g. different K M values), or are regulated differently.
218 11670 Ensembl ENSG00000108602 ENSMUSG00000019102 UniProt P30838 P47739 RefSeq (mRNA) NM_000691 NM_001135167 NM_001135168 NM_001330150 NM_001112725 NM_007436 NM_001331112 RefSeq (protein) NP_000682 NP_001128639 NP_001128640 NP_001317079 NP_001106196 NP_001318041 NP_031462 Location (UCSC) Chr 17: 19.74 – 19.75 Mb Chr 11: 61.1 – 61.11 Mb PubMed search Wikidata View/Edit Human View/Edit ...
212647 Ensembl ENSG00000159423 ENSMUSG00000028737 UniProt P30038 Q8CHT0 RefSeq (mRNA) NM_001161504 NM_003748 NM_170726 NM_001319218 NM_175438 RefSeq (protein) NP_001154976 NP_001306147 NP_003739 NP_733844 NP_780647 Location (UCSC) Chr 1: 18.87 – 18.9 Mb Chr 4: 139.35 – 139.38 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Delta-1-pyrroline-5-carboxylate dehydrogenase ...
The alcohol dehydrogenases comprise a group of several isozymes that catalyse the oxidation of primary and secondary alcohols to aldehydes and ketones, respectively, and also can catalyse the reverse reaction. [19] In mammals this is a redox (reduction/oxidation) reaction involving the coenzyme nicotinamide adenine dinucleotide (NAD ...
ALDH1a2 also works in conjunction with ALDH1a1 to establish sufficient retinoic acid levels in the testes to support spermatogenesis. [11] Due to its role in suppressing immune cells as well as its unique amplification in T cell Acute Lymphoblastic Leukemia (T-ALL), ALDH1a2 has been suggested as a target for cancer therapy.