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  2. Anti-nRNP - Wikipedia

    en.wikipedia.org/wiki/Anti-nRNP

    Anti-nRNP is a type of antibody. [1] [2] They are autoantibodies against some ribonucleoproteins. [3]

  3. Extractable nuclear antigen - Wikipedia

    en.wikipedia.org/wiki/Extractable_nuclear_antigen

    An extractable nuclear antigen panel, or an ENA panel, tests for presence of autoantibodies in the blood that react with proteins in the cell nucleus.It is usually done as a follow-up to a positive antinuclear antibody test and when one is showing symptoms of an autoimmune disorder.

  4. Antinuclear antibody - Wikipedia

    en.wikipedia.org/wiki/Antinuclear_antibody

    Thus, anti-Sm and anti-RNP antibodies were discovered in 1966 and 1971, respectively. In the 1970s, the anti-Ro/anti-SS-A and anti-La/anti-SS-B antibodies were discovered. The Scl-70 antibody was known to be a specific antibody to scleroderma in 1979, however the antigen (topoisomerase-I) was not characterised until 1986.

  5. Nucleoprotein - Wikipedia

    en.wikipedia.org/wiki/Nucleoprotein

    Anti-RNP antibodies are autoantibodies associated with mixed connective tissue disease and are also detected in nearly 40% of Lupus erythematosus patients. Two types of anti-RNP antibodies are closely related to Sjögren's syndrome: SS-A (Ro) and SS-B (La). Autoantibodies against snRNP are called Anti-Smith antibodies and are specific for SLE ...

  6. Mixed connective tissue disease - Wikipedia

    en.wikipedia.org/wiki/Mixed_connective_tissue...

    HLA-DR4 in the MHC is linked to both anti-RNP antibody responses and MCTD. [52] [53] The HLA class II phenotype/genotype most closely connected with scleroderma, HLA-DR5, and its subgroups, has been demonstrated to have a negative connection with MCTD. [54] [55] Another genetic feature of MCTD is the presence of anti-RNP antibodies.

  7. Anti-histone antibodies - Wikipedia

    en.wikipedia.org/wiki/Anti-histone_antibodies

    Anti-histone antibodies are autoantibodies that are a subset of the anti-nuclear antibody family, which specifically target histone protein subunits or histone complexes. [1] They were first reported by Henry Kunkel , H.R. Holman, and H.R.G. Dreicher in their studies of cellular causes of lupus erythematosus in 1959–60.

  8. Immunogenicity - Wikipedia

    en.wikipedia.org/wiki/Immunogenicity

    By calculating the density of high-scoring frames within a protein, it is possible to estimate a protein's overall “immunogenicity score”. In addition, sub-regions of densely packed high scoring frames or “clusters” of potential immunogenicity can be identified, and cluster scores can be calculated and compiled.

  9. Anti-dsDNA antibodies - Wikipedia

    en.wikipedia.org/wiki/Anti-dsDNA_antibodies

    In contrast to the high specificity, estimates of 25–85% have been observed for the sensitivity of anti-dsDNA in SLE. Therefore, presence of anti-dsDNA antibodies are suggestive of SLE, however an absence of the antibodies does not rule out the disease. [1] The levels of circulating anti-dsDNA antibodies fluctuate with disease activity in SLE.

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