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Rhabdomyolysis (shortened as rhabdo) is a condition in which damaged skeletal muscle breaks down rapidly, often due to high intensity exercise over a short period. [6] [4] [5] Symptoms may include muscle pains, weakness, vomiting, and confusion. [3] [4] There may be tea-colored urine or an irregular heartbeat.
These systemic effects are caused by a traumatic rhabdomyolysis. As muscle cells die, they absorb sodium, water, and calcium; the rhabdomyolysis releases potassium, myoglobin, phosphate, thromboplastin, creatine, and creatine kinase. [citation needed] Crush syndrome can directly come from compartment syndrome, if the injury is left untreated. [8]
Muscle degeneration from rhabdomyolysis destroys the myosin and actin filaments in the affected tissue. This initiates the body's natural reaction to increasing perfusion to the area allowing for an influx of specialized cells to repair the injury. However, the swelling increases the intracellular pressure beyond normal limits.
Rhabdomyolysis can cause kidney damage, and it can be life-threatening if not treated properly. ... Collins added that, due to the extent of the injuries, the university will be appointing an ...
Myoglobinuria pathophysiology consists of a series of metabolic actions in which damage to muscle cells affect calcium mechanisms, thereby increasing free ionized calcium in the cytoplasm of the myocytes (concurrently decreasing free ionized calcium in the bloodstream). This, in turn, affects several intracellular enzymes that are calcium ...
The pressure keeps rising due to the non-compliant fascia in the compartment. [5] This cycle can cause tissue ischemia, a lack of oxygen, and necrosis, or tissue death. [6] [5] [43] Paresthesia, or tingling, can start as early as 30 minutes after tissue ischemia begins. [45] Permanent damage can occur 12 hours after the injury starts. [45]
Abdominal CT showing left renal artery injury. Blunt abdominal trauma (BAT) represents 75% of all blunt trauma and is the most common example of this injury. [3] Seventy-five percent of BAT occurs in motor vehicle crashes, [4] in which rapid deceleration may propel the driver into the steering wheel, dashboard, or seatbelt, [5] causing contusions in less serious cases, or rupture of internal ...
A crush injury is injury by an object that causes compression of the body. [1] [2] This form of injury is rare in normal civilian practice, but common following a natural disaster. [3] Other causes include industrial accidents, road traffic collisions, building collapse, accidents involving heavy plant, disaster relief or terrorist incidents. [4]