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A peptidomimetic is a small protein-like chain designed to mimic a peptide. [ 1 ] [ 2 ] They typically arise either from modification of an existing peptide, or by designing similar systems that mimic peptides, such as peptoids and β-peptides .
Prohibitin-targeting peptide 1 (also known as prohibitin-TP01 and TP01; trade name Adipotide) is a peptidomimetic with sequence CKGGRAKDC-GG-D (KLAKLAK) 2. It is an experimental proapoptotic drug [ 1 ] that has been shown to cause rapid weight loss in mice [ 2 ] and rhesus monkeys. [ 3 ]
Saquinavir is effective against both HIV-1 and HIV-2 [5] and is usually well tolerated but high serum concentration is not achieved. [11] Ritonavir, a peptidomimetic HIV protease inhibitor, was marketed in 1996. [18] It was designed to fit the C2-symmetry in the binding site of the protease. [6]
Peptoids (root from the Greek πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest" and the Greek-derived suffix -oid meaning "like, like that of, thing like a _____," ), or poly-N-substituted glycines, are a class of biochemicals known as biomimetics that replicate the behavior of biological molecules. [1]
Therapeutic drug monitoring (TDM) is a branch of clinical chemistry and clinical pharmacology that specializes in the measurement of medication levels in blood.Its main focus is on drugs with a narrow therapeutic range, i.e. drugs that can easily be under- or overdosed. [1]
The Nurses' Health Study 1 contained populations representing nurses of the time, but did not reflect great diversity. The participants had a slightly higher income than the average of the time and a majority were white (97%). [5] In 2012, however, minority participants were increasingly sought after. [40]
In enzymology, a peptide deformylase (EC 3.5.1.88) is an enzyme that removes the formyl group from the N terminus of nascent polypeptide chains in eubacteria, mitochondria and chloroplasts. [1] Peptide deformylases are metaloenzymes monomers and bind a metal cofactor, typically Fe(II) or Zn, in an active site. Cofactor identity impacts ...
The results of the study showed that the most effective treatment was the three drug treatment. After 24 weeks of treatment, 24 patients of the 28 patients who were treated with the three drugs were able to have viral load levels have less than 500 copies/ml. 12 out of 28 patients under indinavir monotherapy reached 500 copies/ml, and none of ...