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Eurycomanone is a chemical compound that has been isolated from Eurycoma longifolia, also known as the longjack plant or tongkat ali. [1] Eurycomanone is distributed throughout the plant, with the highest concentration in leaves. Researchers measured 6.0568 μg/mL in leaves, and only 0.3533 μg/mL in roots. [2]
Eurycoma longifolia (commonly called tongkat ali, Malaysian ginseng or long jack) [3] is a flowering plant in the family Simaroubaceae. It is native to Indochina (Cambodia, Laos, Malaysia, Myanmar, Thailand and Vietnam) and Indonesia (the islands of Borneo and Sumatra ), [ 4 ] but has also been found in the Philippines. [ 5 ]
Tongkat Ali, a south-east Asian medicinal plant (also called Eurycoma longifolia Jack or Malaysian ginseng), is one of the most commonly touted testosterone-boosting herbs.
Damage to DNA that occurs naturally can result from metabolic or hydrolytic processes. Metabolism releases compounds that damage DNA including reactive oxygen species, reactive nitrogen species, reactive carbonyl species, lipid peroxidation products, and alkylating agents, among others, while hydrolysis cleaves chemical bonds in DNA. [8]
When DNA is damaged such as due to a lesion, a complex signal transduction pathway is activated which is responsible for recognizing the damage and instigating the cell's response for repair. Compared to the other lesion repair mechanisms, DDR is the highest level of repair and is employed for the most complex lesions.
The specific type of damage is determined by the size of the colonies, distinguishing between genetic mutations (mutagens) and chromosomal aberrations (clastogens). [6] The SOS/umu assay test evaluates the ability of a substance to induce DNA damage; it is based on the alterations in the induction of the SOS response due to DNA damage. The ...
Tongkat Ali (a.k.a. Long Jack) is marketed by several off-shore sources, trumpeted as a testosterone booster, without the side-effects of direct testosterone supplementation. In what appear to be limited trials, results reported include 200% to 400% increase in testosterone and free testerone levels. This seems remarkable.
An arsenal of DNA repair mechanisms exists to repair various forms of damaged DNA and minimize genomic instability. Most DNA repair mechanisms require an intact DNA strand as template to fix the damaged strand. DNA damage prevents the normal enzymatic synthesis of DNA by the replication fork.
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