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  2. Interferon-stimulated gene - Wikipedia

    en.wikipedia.org/wiki/Interferon-stimulated_gene

    ISGs are genes whose expression can be stimulated by interferon, but may also be stimulated by other pathways. [1] Interferons are a type of protein called a cytokine, which is produced in response to infection. [9] When released, they signal to infected cells and other nearby cells that a pathogen is present. [9]

  3. ISG15 - Wikipedia

    en.wikipedia.org/wiki/ISG15

    Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. [ 5 ] [ 6 ] ISG15 is induced by type I interferon (IFN) and serves many functions, acting both as an extracellular cytokine and an intracellular protein modifier.

  4. Interferome - Wikipedia

    en.wikipedia.org/wiki/Interferome

    These Interferon Regulated Genes are also known as Interferon Stimulated Genes (ISGs). The database contains information on type I (IFN alpha, beta), type II (IFN gamma) and type III (IFN lambda) regulated genes and is regularly updated. It is used by the interferon and cytokine research community [2] both as an analysis tool and an information ...

  5. Stimulator of interferon genes - Wikipedia

    en.wikipedia.org/wiki/Stimulator_of_interferon_genes

    Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. [ 5 ] STING plays an important role in innate immunity .

  6. Interferon alpha-1 - Wikipedia

    en.wikipedia.org/wiki/Interferon_alpha-1

    Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene. [3] [4] Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon (IFN-gamma; MIM 147570) is produced by mitogen- or antigen-stimulated T lymphocytes.[supplied by OMIM] [4]

  7. Interferon-alpha/beta receptor - Wikipedia

    en.wikipedia.org/wiki/Interferon-alpha/beta_receptor

    For example, type I IFNs induce interferon-stimulated gene expression, classically resulting in a robust anti-viral immune response. Additionally, IFNs largely impact cell health and viability, with effects on apoptosis, autophagy, cell differentiation, and proliferation. [10]

  8. IFNA2 - Wikipedia

    en.wikipedia.org/wiki/IFNA2

    The gene encoding IFNα2, the IFNA2 gene, is clustered with all other type I IFN genes on chromosome 9 [8] and as all type I IFN genes, it is devoid of intron. [9] The open reading frame (coding sequence) of IFNA2 codes for a pre-protein of 188 amino acids with a 23 amino acid signal peptide allowing secretion of the mature protein.

  9. IFITM1 - Wikipedia

    en.wikipedia.org/wiki/IFITM1

    Interferon-induced transmembrane protein 1 is a protein that in humans is encoded by the IFITM1 gene. [ 3 ] [ 4 ] IFITM1 has also recently been designated CD225 ( cluster of differentiation 225). This protein has several additional names: fragilis (human homolog of the mouse protein), IFI17 [interferon-induced protein 17], 9-27 [Interferon ...