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Several treatment methods are available for GTN that include surgery, chemotherapy or combination of these. Surgery treatment is most common initial method for some types of the disease but it depends on the stage of the tumor. Common surgical options include dilation and curettage, and hysterectomy.
A placental site trophoblastic tumor is a monophasic neoplasm of the implantation site intermediate trophoblast, and usually a benign lesion, which comprises less than 2% of all gestational trophoblastic proliferations. Preceding conditions include molar pregnancy (5%).
Both are composed of intermediate trophoblast, but their morphological features and clinical presentation can differ significantly. Exaggerated placental site is a benign, non cancerous lesion with an increased number of implantation site intermediate trophoblastic cells that infiltrate the endometrium and the underlying myometrium .
The trophoblast (from Greek trephein: to feed; and blastos: germinator) is the outer layer of cells of the blastocyst. Trophoblasts are present four days after fertilization in humans. [ 1 ] They provide nutrients to the embryo and develop into a large part of the placenta .
4 Treatment. 5 Prognosis. 6 References. ... It is a trophoblastic tumor of neoplastic chorionic type associated with the intermediate trophoblast. Signs and symptoms
Gestational choriocarcinoma is a form of gestational trophoblastic neoplasia, which is a type of gestational trophoblastic disease (GTD), that can occur during pregnancy.It is a rare disease where the trophoblast, a layer of cells surrounding the blastocyst, undergoes abnormal developments, leading to trophoblastic tumors.
5T4 is an antigen expressed in a number of carcinomas. [7] It is an N-glycosylated transmembrane 72 kDa glycoprotein containing eight leucine-rich repeats. [6] 5T4 is often referred to as an oncofetal antigen due to its expression in foetal trophoblast (where it was first discovered) or trophoblast glycoprotein (TPBG).
Implantation site intermediate trophoblast. Low molecular weight cytokeratin stain. Intermediate trophoblast is a distinct subtype of trophoblastic tissue that arises from the cytotrophoblast. [1] It is sub-categorized by location: [1] Villous intermediate trophoblast: at anchoring villi of trophoblastic column; Implantation site intermediate ...