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Baroreflex activation therapy is an approach to treating high blood pressure and the symptoms of heart failure. It uses an implanted device to electrically stimulate baroreceptors in the carotid sinus region. This elicits a reflex response through the sympathetic and vagal nervous systems that reduces blood pressure.
The carotid sinus baroreceptor can be oversensitive to manual stimulation from the pressure applied at the carotid sinus at the carotid bifurcation. It is a condition known as 'carotid sinus hypersensitivity' (CSH), 'carotid sinus syndrome' or 'carotid sinus syncope', in which manual stimulation causes large changes in heart rate and blood ...
Flowchart showing baroreceptor reflex. The baroreflex or baroreceptor reflex is one of the body's homeostatic mechanisms that helps to maintain blood pressure at nearly constant levels. The baroreflex provides a rapid negative feedback loop in which an elevated blood pressure causes the heart rate to decrease. Decreased blood pressure decreases ...
It conveys information from the baroreceptors of the carotid sinus to the vasomotor center in the brainstem (in order to mediate blood pressure homeostasis), and from chemoreceptors of the carotid body [further explanation needed] (mainly conveying information about partial pressures of blood oxygen, and carbon dioxide).
Baroreceptors can also become oversensitive in some people (usually the carotid baroreceptors in older males). This can lead to bradycardia, dizziness and fainting (syncope) from touching the neck (often whilst shaving). This is an important cause to exclude in men having pre-syncope or syncope symptoms.
Reflex bradycardia is a bradycardia (decrease in heart rate) in response to the baroreceptor reflex, one of the body's homeostatic mechanisms for preventing abnormal increases in blood pressure. In the presence of high mean arterial pressure , the baroreceptor reflex produces a reflex bradycardia as a method of decreasing blood pressure by ...
The carotid body is a small cluster of peripheral chemoreceptor cells and supporting sustentacular cells situated at the bifurcation of each common carotid artery in its tunica externa. [ 1 ] [ 2 ] The carotid body detects changes in the composition of arterial blood flowing through it, mainly the partial pressure of arterial oxygen , but also ...
Carotid sinus syncope is due to pressure on the carotid sinus in the neck. [2] The underlying mechanism involves the nervous system slowing the heart rate and dilating blood vessels, resulting in low blood pressure and thus not enough blood flow to the brain. [2] Diagnosis is based on the symptoms after ruling out other possible causes. [3]