Search results
Results from the WOW.Com Content Network
Specialty. Hematology. Paroxysmal nocturnal hemoglobinuria ( PNH) is a rare, acquired, [1] life-threatening disease of the blood characterized by destruction of red blood cells by the complement system, a part of the body's innate immune system. This destructive process occurs due to deficiency of the red blood cell surface protein DAF, which ...
Pathophysiology. Cold agglutinins, or cold autoantibodies, occur naturally in nearly all individuals. These natural cold autoantibodies occur at low titers, less than 1:64 measured at 4 °C, and have no activity at higher temperatures. Pathologic cold agglutinins occur at titers over 1:1000 and react at 28-31 °C and sometimes at 37 °C.
Paroxysmal cold hemoglobinuria. Paroxysmal cold hemoglobinuria ( PCH) or Donath–Landsteiner hemolytic anemia ( DLHA) is an autoimmune hemolytic anemia featured by complement -mediated intravascular hemolysis after cold exposure. [1] It can present as an acute non-recurrent postinfectious event in children, or chronic relapsing episodes in ...
Hemoglobinuria. Hemoglobinuria is a condition in which the oxygen transport protein hemoglobin is found in abnormally high concentrations in the urine. [1] The condition is caused by excessive intravascular hemolysis, in which large numbers of red blood cells (RBCs) are destroyed, thereby releasing free hemoglobin into the plasma. [2]
Postural orthostatic tachycardia syndrome (POTS) is a condition characterized by an abnormally large increase in heart rate upon sitting up or standing. [1] POTS is a disorder of the autonomic nervous system that can lead to a variety of symptoms, [10] including lightheadedness, brain fog, blurred vision, weakness, fatigue, headaches, heart palpitations, exercise intolerance, nausea ...
Tachycardia-induced cardiomyopathy. Tachycardia-induced cardiomyopathy (TIC) is a disease where prolonged tachycardia (a fast heart rate) or arrhythmia (an irregular heart rhythm) causes an impairment of the myocardium (heart muscle), which can result in heart failure. [1] [5] People with TIC may have symptoms associated with heart failure (e.g ...
Cold antibody autoimmune hemolytic anemia; Paroxysmal cold hemoglobinuria; Drug-induced autoimmune hemolytic anemia; Alloimmune hemolytic anemia. Hemolytic disease of the newborn (HDN) Rh disease (Rh D) ABO hemolytic disease of the newborn; Anti-Kell hemolytic disease of the newborn; Rhesus c hemolytic disease of the newborn
Autoimmune hemolytic anemia ( AIHA) is an autoimmune disorder which occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst ( lyse ), leading to an insufficient number of oxygen-carrying red blood cells in circulation ( anemia ). The lifetime of the RBCs is reduced from the normal 100–120 days to ...