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Structure of a G-quadruplex. Left: a G-tetrad. Right: an intramolecular G4 complex. [1]: fig1 In molecular biology, G-quadruplex secondary structures (G4) are formed in nucleic acids by sequences that are rich in guanine. [2] They are helical in shape and contain guanine tetrads that can form from one, [3] two [4] or four strands. [5]
DNAzyme research for the treatment of cancer is also underway. The development of a 10-23 DNAzyme that can block the expression of IGF-I (Insulin-like growth factor I, a contributor to normal cell growth as well as tumorigenesis) by targeting its mRNA could be useful for blocking the secretion of IGF-I from prostate storm primary cells ...
This definition of immortality has been challenged in the Handbook of the Biology of Aging, [1] because the increase in rate of mortality as a function of chronological age may be negligible at extremely old ages, an idea referred to as the late-life mortality plateau. The rate of mortality may cease to increase in old age, but in most cases ...
Afanas'ev suggests the superoxide dismutation activity of CuZnSOD demonstrates an important link between life span and free radicals. [33] The link between CuZnSOD and life span was demonstrated by Perez et al. who indicated mice life span was affected by the deletion of the Sod1 gene which encodes CuZnSOD. [34]
Life extension – study of slowing down or reversing the processes of aging to extend both the maximum and average lifespan. Also known as anti-aging medicine , experimental gerontology , and biomedical gerontology .
Methylation of histones has been tied to life span regulation in many organisms, specifically H3K4me3, an activating mark, and H4K27me3, a repressing mark. In C. elegans , the loss of any of the three Trithorax proteins that catalyze the trimethylation of H3K4 such as, WDR-5 and the methyltransferases SET-2 and ASH-2, lowers the levels of ...
The earliest evidence for life on Earth includes: 3.8 billion-year-old biogenic hematite in a banded iron formation of the Nuvvuagittuq Greenstone Belt in Canada; [30] graphite in 3.7 billion-year-old metasedimentary rocks in western Greenland; [31] and microbial mat fossils in 3.48 billion-year-old sandstone in Western Australia.
Some tortoises show negligible senescence. Negligible senescence is a term coined by biogerontologist Caleb Finch to denote organisms that do not exhibit evidence of biological aging (), such as measurable reductions in their reproductive capability, measurable functional decline, or rising death rates with age. [1]