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Korsakoff syndrome (KS) [1] is a disorder of the central nervous system characterized by amnesia, deficits in explicit memory, and confabulation. This neurological disorder is caused by a deficiency of thiamine (vitamin B 1 ) in the brain, and it is typically associated with and exacerbated by the prolonged, excessive ingestion of alcohol . [ 2 ]
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Wernicke-Korsakoff syndrome (WKS) is the combined presence of Wernicke encephalopathy (WE) and alcoholic Korsakoff syndrome (AKS [clarification needed]). Due to the close relationship between these two disorders, people with either are usually diagnosed with WKS as a single syndrome.
Up to 80% of WE patients who misuse alcohol develop Korsakoff's syndrome. [39] In Korsakoff's, is usually observed atrophy of the thalamus and the mammillary bodies, and frontal lobe involvement. [39] In a study, half of Wernicke–Korsakoff cases had good recovery from the amnesic state, which may take from 2 months to 10 years. [2]
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It has embarked on a S$4.4-million three-year nationwide epidemiological study – Well-being of the Singapore Elderly (WiSE) – that aims to establish high-quality data of the burden of dementia and depression among the elderly in Singapore and to bridge the knowledge gap on the associated risk factors, healthcare use and economic impact.
Temasek Cares CLG Ltd was founded in 2009 through a grant of S$100 million to the Temasek Trust, an initial endowment gift to fund Singapore community programmes. [7] An additional endowment of $70 million –renamed as the Ee Peng Liang Endowment and the Balaji Sadasivan Endowment –was received on its first anniversary. [ 8 ]
Sergei Korsakov was the first great Russian neuropsychiatrist. He studied medicine at the Moscow State University, graduated in 1875 and subsequently became a physician at the "Preobrazhenski" (Russian: Преображенский) mental hospital.