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The non-template (sense) strand of DNA is called the coding strand, because its sequence is the same as the newly created RNA transcript (except for the substitution of uracil for thymine). This is the strand that is used by convention when presenting a DNA sequence.
The sense strand is the strand of DNA that has the same sequence as the mRNA, which takes the antisense strand as its template during transcription, and eventually undergoes (typically, not always) translation into a protein. The antisense strand is thus responsible for the RNA that is later translated to protein, while the sense strand ...
However, the DNA sense strand itself is not used as the template for the mRNA; it is the DNA antisense strand that serves as the source for the protein code, because, with bases complementary to the DNA sense strand, it is used as a template for the mRNA.
By convention, the coding strand is the strand used when displaying a DNA sequence. It is presented in the 5' to 3' direction. Wherever a gene exists on a DNA molecule, one strand is the coding strand (or sense strand), and the other is the noncoding strand (also called the antisense strand, [3] anticoding strand, template strand or transcribed ...
This RNA is complementary to the template 3′ → 5′ DNA strand, [1] with the exception that thymines (T) are replaced with uracils (U) in the RNA and possible errors. In bacteria, transcription is carried out by a single type of RNA polymerase, which needs to bind a DNA sequence called a Pribnow box with the help of the sigma factor protein ...
Based on the Watson-Crick model, he envisaged that the DNA itself is a direct template for protein synthesis. [18] Assuming that the four bases of DNA could produce 20 different combinations as triplets, he suggested that the different amino acids must correspond to a twenty-letter alphabet of the nucleotide sequence. [ 19 ]
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The movement of the RNA-DNA complex is essential for the catalytic mechanism of RNA polymerase. Additionally, RNA polymerase increases the overall stability of this process by acting as a link between the RNA and DNA strands. [18] New nucleotides that are complementary to the DNA template strand are added to the 3' end of the RNA strand. [4]