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The timing hypothesis, gap hypothesis, gap theory, or critical window hypothesis for menopausal hormone therapy is a scientific theory that the benefits and risks of menopausal hormone therapy vary depending on the amount of time a woman has been in menopause upon initiation of treatment.
The Early versus Late Intervention Trial with Estradiol (ELITE) was a large randomized controlled trial that assessed the timing hypothesis that menopausal hormone therapy in early but not late menopause would improve cardiovascular outcomes. [1] [2]
The design of the hormone therapy trial (HT) was approached with the hypothesis that estrogen therapy would result in a decrease in coronary heart disease and osteoporosis-related fractures. As such, the primary outcome of interest was coronary heart disease, as this is a major cause of morbidity and mortality among women, particularly those ...
How to Reset Female Hormones For Weight Loss. This article was reviewed by Craig Primack, MD, FACP, FAAP, MFOMA. Hormones can be helpful heroes, supporting the immune system and a healthy sleep ...
Hormone therapy or hormonal therapy is the use of hormones in medical treatment. Treatment with hormone antagonists may also be referred to as hormonal therapy or antihormone therapy . The most general classes of hormone therapy are oncologic hormone therapy , hormone replacement therapy (for menopause), androgen replacement therapy (ART), oral ...
Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. [ 1 ] [ 2 ] Effects of menopause can include symptoms such as hot flashes , accelerated skin aging, vaginal dryness , decreased muscle mass , and ...
An estrogen (E) is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy, and as part of feminizing hormone therapy for transgender women. [1] They can also be used in the treatment of hormone-sensitive cancers like breast cancer and prostate cancer and for various other indications.
[10] [2] At the physiological level, menopause happens because of a decrease in the ovaries' production of the hormones estrogen and progesterone. [1] While typically not needed, a diagnosis of menopause can be confirmed by measuring hormone levels in the blood or urine. [11] Menopause is the opposite of menarche, the time when a girl's periods ...
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