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Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]
This condition was first discovered in 1995 by Melberg et al. when they described 5 members of a 4-generation Swedish family where cerebellar ataxia and sensorineural deafness presented as an autosomal dominant trait, 4 of them had narcolepsy and 2 had diabetes mellitus. The oldest members had psychiatric symptoms, neurological anomalies, and ...
Narcoleap is a Canadian web series created by Kate Green. [1] The series stars Chelsey Reist, Madison Smith, Austin Eckhert, Nicole Oliver, Aleks Paunovic, Cameron Bancroft, and Nhi Do, and is loosely based on the original concept by Donald Auger. [2]
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At the launch of NT1 in 2005, it aired children's cartoons in the morning. [15] In the 2010s, NT1 did air live-action programming for children in the morning such as Violetta. [16] Since 8 January 2024, TFX share the children's programming block TFOU with TF1 on weekdays, airing it from 6.55 a.m. to 8.30 a.m., and until 9.30 a.m. on Wednesdays.
The full mechanism of action of sodium oxybate is poorly understood. [ 3 ] [ 7 ] GHB is a normal metabolite of GABA that interacts with the GABA B receptor and the GHB receptor . [ 3 ] It has been shown to enhance the restorativeness of sleep in part by altering sleep architecture in narcoleptic patients.
Narcolepsy with cataplexy is considered an autoimmune-mediated disorder, so some therapies based on this hypothesis have been developed. Immunological therapies developed include: [ 20 ] Corticosteroids : after testing in 1 human and 1 canine case it proved to be ineffective so is less likely to be further used.
Methylphenidate, sold under the brand names Ritalin (/ ˈ r ɪ t ə l ɪ n / RIT-ə-lin) and Concerta (/ k ə n ˈ s ɜːr t ə / kən-SUR-tə) [citation needed] among others, is a central nervous system (CNS) stimulant indicated in the pharmacotherapy of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
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