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Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]
The skeletal structure of norepinephrine The skeletal structure of dopamine. A norepinephrine–dopamine reuptake inhibitor (NDRI) is a drug used for the treatment of clinical depression, attention deficit hyperactivity disorder (ADHD), narcolepsy, and the management of Parkinson's disease.
This condition was first discovered in 1995 by Melberg et al. when they described 5 members of a 4-generation Swedish family where cerebellar ataxia and sensorineural deafness presented as an autosomal dominant trait, 4 of them had narcolepsy and 2 had diabetes mellitus. The oldest members had psychiatric symptoms, neurological anomalies, and ...
Amphetamine [note 2] (contracted from alpha-methylphenethylamine) is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity; it is also used to treat binge eating disorder in the form of its inactive prodrug lisdexamfetamine.
The full mechanism of action of sodium oxybate is poorly understood. [ 3 ] [ 7 ] GHB is a normal metabolite of GABA that interacts with the GABA B receptor and the GHB receptor . [ 3 ] It has been shown to enhance the restorativeness of sleep in part by altering sleep architecture in narcoleptic patients.
At the launch of NT1 in 2005, it aired children's cartoons in the morning. [15] In the 2010s, NT1 did air live-action programming for children in the morning such as Violetta. [16] Since 8 January 2024, TFX share the children's programming block TFOU with TF1 on weekdays, airing it from 6.55 a.m. to 8.30 a.m., and until 9.30 a.m. on Wednesdays.
Narcolepsy with cataplexy is considered an autoimmune-mediated disorder, so some therapies based on this hypothesis have been developed. Immunological therapies developed include: [ 20 ] Corticosteroids : after testing in 1 human and 1 canine case it proved to be ineffective so is less likely to be further used.
Solriamfetol is used to promote wakefulness in the treatment of excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea in adults. [1] It appears to be more effective in improving excessive daytime sleepiness associated with obstructive sleep apnea than certain other wakefulness-promoting agents including modafinil, armodafinil, and pitolisant.
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