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In biology, hypochlorous acid is generated in activated neutrophils by myeloperoxidase-mediated peroxidation of chloride ions, and contributes to the destruction of bacteria. [13] [14] [15] In medicine, hypochlorous acid water has been used as a disinfectant and sanitiser. [6] [9] [5]
Hypochlorous acid is normally produced by myeloperoxidase Myeloperoxidase deficiency is a disorder featuring lack in either the quantity or the function of myeloperoxidase –an iron-containing protein expressed primarily in neutrophil granules.
Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. [5] MPO is most abundantly expressed in neutrophils (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity, including hypochlorous acid, the sodium salt of which is the chemical in bleach.
Hypochlorous acid (HOCl) is a naturally occurring compound produced by our white blood cells to fight infection and inflammation, says Mona Gohara, M.D., board-certified dermatologist at ...
There’s hyaluronic acid, salicylic acid and even polyglutamic acid. But the ingredient I’ve noticed garnering the most attention on social media lately is hypochlorous acid. Said to destroy ...
Hypochlorous acid is good for a range of skin conditions—it works for eczema, rosacea, sunburn, minor cuts, bug bites, redness, irritation, and more. It’s even beneficial for recovering from ...
Integral to hypochlorous acid formation is myeloperoxidase. Myeloperoxidase is most abundant in neutrophils, wherein phagocytosis is accompanied by degranulation. This is the fusion of granules with the phagolysosome, releasing their contents, including myeloperoxidase. [10]
During inflammation, neutrophil-derived myeloperoxidase produces hypochlorous acid, which causes oxidative chlorination of plasmalogens at the sn-1 chain by reacting with the vinyl ether bond. [26] Several researchers are currently investigating the impact of chlorinated lipids on pathology.