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  2. Melatonin receptor agonist - Wikipedia

    en.wikipedia.org/wiki/Melatonin_receptor_agonist

    Agonists of the melatonin receptor have a number of therapeutic applications including treatment of sleep disorders and depression. The discovery and development of melatonin receptor agonists was motivated by the need for more potent analogues than melatonin, with better pharmacokinetics and longer half-lives. Melatonin receptor agonists were ...

  3. Agomelatine - Wikipedia

    en.wikipedia.org/wiki/Agomelatine

    Agomelatine, sold under the brand names Valdoxan and Thymanax, among others, is an atypical antidepressant most commonly used to treat major depressive disorder and generalized anxiety disorder. [8] One review found that it is as effective as other antidepressants with similar discontinuation rates overall but fewer discontinuations due to side ...

  4. Melatonin as a medication and supplement - Wikipedia

    en.wikipedia.org/wiki/Melatonin_as_a_medication...

    Melatonin is a safer alternative than clonazepam in the treatment of REM sleep behavior disorder – a condition associated with the synucleinopathies like Parkinson's disease and dementia with Lewy bodies. [32] [33] [34] However, clonazepam may be more effective. [35]

  5. Can You Use Melatonin for Anxiety? Here’s What You ... - AOL

    www.aol.com/melatonin-anxiety-know-221319222.html

    Melatonin has become the go-to supplement for helping Americans get a good night’s sleep. According to a 2020 survey from the Council for Responsible Nutrition (CRN), 66 percent of people who ...

  6. Melatonin receptor - Wikipedia

    en.wikipedia.org/wiki/Melatonin_receptor

    Melatonin receptors are G protein-coupled receptors (GPCR) which bind melatonin. [1] Three types of melatonin receptors have been cloned.The MT 1 (or Mel 1A or MTNR1A) and MT 2 (or Mel 1B or MTNR1B) receptor subtypes are present in humans and other mammals, [2] while an additional melatonin receptor subtype MT 3 (or Mel 1C or MTNR1C) has been identified in amphibia and birds. [3]

  7. Hypnotic - Wikipedia

    en.wikipedia.org/wiki/Hypnotic

    Melatonin, the hormone produced in the pineal gland in the brain and secreted in dim light and darkness, among its other functions, promotes sleep in diurnal mammals. [35] synthetic analogues of melatonin, or melatonin receptor agonists, have also been made. Among these, ramelteon and tasimelteon are used for sleep-related disorders.

  8. Melatonin - Wikipedia

    en.wikipedia.org/wiki/Melatonin

    Melatonin is used both as a prescription medication and an over-the-counter dietary supplement for the management of sleep disorders, including insomnia and various circadian rhythm sleep disorders such as delayed sleep phase disorder, jet lag disorder, and shift work sleep disorder. [55] In addition to melatonin, a range of synthetic melatonin ...

  9. N-Acetylserotonin - Wikipedia

    en.wikipedia.org/wiki/N-Acetylserotonin

    N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin. [1] [2] It also has biological activity in its own right, including acting as a melatonin receptor agonist, an agonist of the TrkB, and having antioxidant effects.