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Image of CD4 co-receptor binding to MHC (Major Histocompatibility Complex) non-polymorphic region. In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as helper T cells, monocytes, macrophages, and dendritic cells.
The CD family of co-receptors are a well-studied group of extracellular receptors found in immunological cells. [4] The CD receptor family typically act as co-receptors, illustrated by the classic example of CD4 acting as a co-receptor to the T cell receptor (TCR) to bind major histocompatibility complex II (MHC-II). [5]
CD4-Ig works by mimicking the binding of CD4 to HIV, thereby preventing the virus from infecting T-helper cells. HIV infects T-helper cells by binding to the CD4 receptor and the co-receptor CCR5 or CXCR4. CD4-Ig binds to the viral envelope glycoprotein gp120, which is responsible for HIV binding to CD4. By binding to gp120, CD4-Ig prevents the ...
Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system. It serves a number of critical functions in immunity, tolerance, and autoimmunity with the other numerous components.
Exposed on the surface of the viral envelope, the glycoprotein gp120 binds to the CD4 receptor on any target cell that has such a receptor, particularly the helper T-cell. Strains of HIV-1 have been isolated that are able to enter host cells that are CD4 negative. This CD4-independence is associated with spontaneous mutation in the env gene.
The term comes from the specification for Common Lisp, which explicitly refers to the programming language feature enabling for inter-language calls as such; [citation needed] the term is also often used officially by the interpreter and compiler documentation for Haskell, [1] Rust, [2] PHP, [3] Python, and LuaJIT [4] [5]: 35 . [6]
CPython is the reference implementation of the Python programming language. Written in C and Python, CPython is the default and most widely used implementation of the Python language. CPython can be defined as both an interpreter and a compiler as it compiles Python code into bytecode before interpreting it.
Nuitka (pronounced as / n juː t k ʌ / [2]) is a source-to-source compiler which compiles Python code to C source code, applying some compile-time optimizations in the process such as constant folding and propagation, built-in call prediction, type inference, and conditional statement execution.