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Blood tests may show low levels of vitamin B 12, elevated levels of methylmalonic acid or homocysteine, and a routine complete blood counts may shows anemia with an elevated mean cell volume. [141] The presence of antibodies to gastric parietal cells and intrinsic factor may indicate pernicious anemia .
“A B12 deficiency can cause physical and neurological symptoms, and research is also growing to support that it can also cause psychological issues as well,” says Shapiro. The list of ...
Folate deficiency, also known as vitamin B 9 deficiency, is a low level of folate and derivatives in the body. [1] This may result in megaloblastic anemia in which red blood cells become abnormally large, and folate deficiency anemia is the term given for this medical condition. [ 3 ]
Vitamin B 12 deficiency prevents the 5-methyltetrahydrofolate (5-MTHF) form of folate from being converted into THF due to the "methyl trap". [18] This disrupts the folate pathway and leads to an increase in homocysteine which damages cells (for example, damage to endothelial cells can result in increased risk of thrombosis). [citation needed]
However, elevated MMA is not conclusive, as it is seen in people with B 12 deficiency, but also in elderly people who have renal insufficiency, [28] and elevated homocysteine is not conclusive, as it is also seen in people with folate deficiency. [52] In addition, elevated methylmalonic acid levels may also be related to metabolic disorders ...
But having lower vitamin B12 levels doesn’t automatically mean that someone’s symptoms are being caused by the deficiency. “B12 deficiency is also more common in people with Alzheimer’s ...
Normal MMA levels indicate folate deficiency and elevated MMA levels indicate vitamin B 12 deficiency. [98] Elevated MMA levels may also be due to the rare metabolic disorder combined malonic and methylmalonic aciduria (CMAMMA). [117] [118] Folate deficiency is treated with supplemental oral folic acid of 400 to 1000 μg per day.
Vitamin B12 deficiency causes symptoms like fatigue, poor memory, a swollen tongue, and canker sores. Skip to main content. 24/7 Help. For premium support please call: 800-290-4726 more ways to ...
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