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Many antibiotics are metabolized in the liver. In patients with liver failure, the use of such antibiotics should be restricted in order to avoid toxicity and subsequent overdose. [17] Erythromycin, clindamycin and metronidazole are antibiotics that would require dose adjustments when administered to patients with liver failure.
Clindamycin is a lincosamide antibiotic medication used for the treatment of a number of bacterial infections, including osteomyelitis (bone) or joint infections, pelvic inflammatory disease, strep throat, pneumonia, acute otitis media (middle ear infections), and endocarditis. [5]
Since most mouth infections are polymicrobial, penicillin is an appropriate initial choice of antibiotic because of its activity against Streptococcus and gram negative anaerobes. If the patient has a penicillin allergy, then clindamycin with or without metronidazole are also effective empiric antibiotic regimens.
Clindamycin alone has been shown to be efficacious in the treatment of acne, [24] toxic shock syndrome [25] and malaria, [26] and to decrease the risk of premature births in women with bacterial vaginosis. [27] Lincosamide antibiotics may also be useful in the treatment of methicillin-resistant S. aureus. [28]
The following is a list of antibiotics. The highest division between antibiotics is bactericidal and bacteriostatic . Bactericidals kill bacteria directly, whereas bacteriostatics prevent them from dividing.
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Common antibiotics used are from the β-lactam antibiotic group, [19] clindamycin [13] and metronidazole. [ 11 ] If there is dysphagia or dyspnoea (difficulty swallowing or breathing), then this usually means there is a severe infection and an emergency admission to hospital is appropriate so that intravenous medications and fluids can be ...
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