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Hydroxyprogesterone caproate, sold under the brand name Delalutin among others, is a medication used to reduce the risk of preterm birth in women pregnant with one baby who have a history of spontaneous preterm birth. [10] In March 2023, the manufacturer, Covis Pharma, agreed to withdraw the drug from the US market.
Certain progestogens are used to support pregnancy, including progesterone, hydroxyprogesterone caproate, dydrogesterone, and allylestrenol. They are used questionably for treatment of recurrent pregnancy loss and for prevention of preterm birth in pregnant women with a history of at least one spontaneous preterm birth. [42]
Levels of progesterone during pregnancy are up to 100-fold higher than during normal menstrual cycling, although levels increase gradually over the course of pregnancy. [135] Oral dosages of progesterone of as high as 3,600 mg/day have been assessed in clinical trials, with the main side effect being sedation. [ 136 ]
DMPA, under brand names such as Depo-Provera and Depo-SubQ Provera 104, is used in hormonal birth control as a long-lasting progestogen-only injectable contraceptive to prevent pregnancy in women. [ 38 ] [ 39 ] It is given by intramuscular or subcutaneous injection and forms a long-lasting depot , from which it is slowly released over a period ...
Progesterone is an endogenous steroid hormone synthesized by the placenta during pregnancy. Progesterone production is regulated by the hypothalamic-pituitary-gonadal axis . The HPG axis regulates the release of both central and peripherally generated ovarian hormones.
An FDA panel recommends that a drug approved to prevent premature birth be removed from the market because it doesn't work and carries risks. Drug meant to prevent premature births should be ...
Estradiol enantate/algestone acetophenide, also known as estradiol enantate/dihydroxyprogesterone acetophenide (E2-EN/DHPA) and sold under the brand names Perlutal and Topasel among others, is a form of combined injectable birth control which is used to prevent pregnancy.
The most prominent side effects of CICs are menstrual irregularities during the first 3 to 6 months of use. [1] Dysmenorrhea has been reported in 30 to 65% of women. [26] Other side effects include breast tenderness/pain, headache, and libido changes. [26] Some fluid retention can occur, but weight gain is minimal. [26]