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Cannabinol, aka CBN, is similar to another p Us Weekly is not endorsing the websites or products set forth below. The use of THC in any capacity may lead to health concerns and users should ...
In the early 1930s, CBN's structure was identified by Cahn, [22] [23] marking the first development of a cannabis extract. Its structure and chemical synthesis were achieved by 1940, followed by some of the first preclinical research studies to determine the effects of individual cannabis-derived compounds in vivo. [8]
CBN was the first cannabis compound to be isolated from cannabis extract in the late 1800s. Its structure and chemical synthesis were achieved by 1940 [34], followed by some of the first pre-clinical research studies to determine the effects of individual cannabis-derived compounds in vivo. [35]
A dried cannabis flower. The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol, and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.
11-Hydroxycannabinol (11-OH-CBN) is the main active metabolite of cannabinol (CBN), one of the active components of cannabis, [1] and has also been isolated from cannabis itself. [2] It is more potent than CBN itself, acting as an agonist of CB 1 with around the same potency as THC , but is a weak antagonist at CB 2 .
As of 2024, the cellular effects and mechanisms of cannabidiol in vivo are unknown, [4] [11] as research to date has been inconclusive and based on laboratory studies. [68] The anticonvulsant effects provided by cannabidiol (Epidiolex) in people with certain forms of epilepsy do not appear to involve cannabinoid receptors. [4]
Cannabichromene (CBC), also called cannabichrome, cannanbichromene, pentylcannabichromene or cannabinochromene, [1] exhibits anti-inflammatory properties in vitro, which may, theoretically, contribute to cannabis analgesic effects. [2] It is a phytocannabinoid, one of the hundreds of cannabinoids found in the Cannabis plant. [3]
Like Δ 9-THC, 11-hydroxy-THC is a partial agonist at the cannabinoid receptor CB 1, but with significantly higher binding affinity (K i = 0.37 nM compared to Δ 9-THC K i = 35 nM). [7] With respect to cAMP inhibition at CB 1 it displays a similar efficacy to that of Δ 9 -THC (EC 50 = 11 nM vs. EC 50 = 5.2 nM, respectively), but a lower ...