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In oncology, the fact that one round of chemotherapy does not kill all the cells in a tumor is a poorly understood phenomenon called fractional kill, or fractional cell kill. The fractional kill hypothesis states that a defined chemotherapy concentration, applied for a defined time period, will kill a constant fraction of the cells in a ...
Hot chemotherapy drugs are pumped directly into the peritoneal cavity to kill the cancer cells. [10] Whole-body hyperthermia heats the entire body to temperatures of about 39 to 43 °C (102 to 109 °F), with some advocating even higher temperatures. It is typically used to treat metastatic cancer (cancer that spread to many parts of the body). [6]
Cancer cells can also cause defects in the cellular pathways of apoptosis (programmed cell death). As most chemotherapy drugs kill cancer cells in this manner, defective apoptosis allows survival of these cells, making them resistant. Many chemotherapy drugs also cause DNA damage, which can be repaired by enzymes in the cell that carry out DNA ...
A professor with the University of Texas at San Antonio has created a new method to kill cancer cells that are traditionally difficult to eradicate. New cancer treatment method causes cells to ...
In conventional chemotherapy, a dose close to the maximum tolerated dose is administered in a bolus manner to achieve cytotoxic effects on tumor cells. [5] However, the side effects are often significant as the cytotoxic agents also kill the fast-dividing cells normally present in the body, such as bone marrow cells and epithelial cells of the gastrointestinal tract. [6]
Not only does nitric oxide stop cell growth, the study shows that it can also induce apoptosis after the cancer cells have been exposed to NO over 48 hours. [ 5 ] Malignant epithelium – Long-chain polyunsaturated fatty acids inhibit cell division, cause cell cycle arrest, and can induce cell death in malignant epithelial cells from various ...
By attaching a chemotherapy drug to an antibody, doctors are able to deliver more potent cancer-fighting medicines directly into tumor cells, all while causing fewer side effects.
The treatment has side effects as healthy cells are damaged alongside cancer cells, and patients can experience tiredness, vomiting, hair loss and have an increased risk of getting infections, dry ...