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27226 Ensembl ENSG00000146070 ENSMUSG00000023913 UniProt Q13093 Q60963 RefSeq (mRNA) NM_001168357 NM_005084 NM_013737 RefSeq (protein) NP_001161829 NP_005075 NP_038765 Location (UCSC) Chr 6: 46.7 – 46.74 Mb Chr 17: 43.88 – 43.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Lipoprotein-associated phospholipase A 2 (Lp-PLA 2) also known as platelet-activating factor ...
Since the first publication by Kansy and coworkers, [7] several companies developed their own versions of the assay. Early models incorporated iso-pH conditions in the compartments separated by a simple lipid membrane; subsequently, commercial products were introduced which incorporated more sophisticated lipid membranes. [8]
The protein of interest is isolated with a specific antibody. Interaction partners which stick to this protein are subsequently identified by Western blotting. [2] Interactions detected by this approach are considered to be real. However, this method can only verify interactions between suspected interaction partners.
Protein–lipid interaction is the influence of membrane proteins on the lipid physical state or vice versa.. The questions which are relevant to understanding of the structure and function of the membrane are: 1) Do intrinsic membrane proteins bind tightly to lipids (see annular lipid shell), and what is the nature of the layer of lipids adjacent to the protein?
Nanodiscs are discoidal proteins in which a lipid bilayer is surrounded by molecules that are amphipathic molecules including proteins, peptides, and synthetic polymers. [2] It is composed of a lipid bilayer of phospholipids with the hydrophobic edge screened by two amphipathic proteins. These proteins are called membrane scaffolding proteins ...
HDL carries many lipid and protein species, several of which have very low concentrations but are biologically very active. For example, HDL and its protein and lipid constituents help to inhibit oxidation, inflammation, activation of the endothelium, coagulation, and platelet aggregation. All these properties may contribute to the ability of ...
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