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Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
The defined daily dose (DDD) is a statistical measure of drug consumption, defined by the World Health Organization (WHO) Collaborating Centre for Drug Statistics Methodology. It is defined in combination with the ATC Code drug classification system for grouping related drugs. The DDD enables comparison of drug usage between different drugs in ...
Outpatient parenteral antibiotic therapy (OPAT) is used to administer non-oral antibiotics (usually intravenously) without the need for ongoing hospitalisation. OPAT is particularly useful for people who are not severely ill but do require a prolonged course of treatment that cannot be given in oral form. [ 1 ]
This vaccine is given as a series of shots, the first dose is given at birth, the second between 1 and 2 months, and the third, and possibly fourth, between 6 and 18 months. Some side effects of this vaccination include: soreness at injection site (1 in 4 children) fever of 99.9 degrees Fahrenheit or higher (1 in 15 children) brief fainting spell
The effects of trimethoprim causes a backlog of dihydrofolate (DHF) and this backlog can work against the inhibitory effect the drug has on tetrahydrofolate biosynthesis. This is where the sulfamethoxazole comes in; its role is in depleting the excess DHF by preventing it from being synthesised in the first place. [14]
In addition, any structural damage, such as lesions or ulcerations, will tend to increase drug absorption. [24] For intramuscular (IM) injection, the absorption is rapid. Paromomycin will reach peak plasma concentration within one hour following IM injection. [3] The in-vitro and in-vivo activities parallel those of neomycin. [25]
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Cefuroxime, sold under the brand name Zinacef among others, is a second-generation cephalosporin [3] antibiotic used to treat and prevent a number of bacterial infections. [4] These include pneumonia, meningitis, otitis media, sepsis, urinary tract infections, and Lyme disease. [5] It is used by mouth or by injection into a vein or muscle. [5]