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  2. Losartan - Wikipedia

    en.wikipedia.org/wiki/Losartan

    Losartan, sold under the brand name Cozaar among others, is a medication used to treat high blood pressure (hypertension). [4] It is in the angiotensin receptor blocker (ARB) family of medication, and is considered protective of the kidneys.

  3. Angiotensin II receptor blocker - Wikipedia

    en.wikipedia.org/wiki/Angiotensin_II_receptor...

    Losartan, the first ARB. Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT 1) antagonists, [1] also known as angiotensin receptor blockers, [2] [3] angiotensin II receptor antagonists, or AT 1 receptor antagonists, are a group of pharmaceuticals that bind to and inhibit the angiotensin II receptor type 1 (AT 1) and thereby block the arteriolar contraction and ...

  4. Discovery and development of angiotensin receptor blockers

    en.wikipedia.org/wiki/Discovery_and_development...

    Losartan, valsartan, candesartan, irbesartan, telmisartan and olmesartan all contain a biphenyl-methyl group. Losartan is partly metabolized to its 5-carboxylic acid metabolite EXP 3174, which is a more potent AT 1 receptor antagonist than its parent compound [17] and has been a model for the continuing development of several other ARBs. [1]

  5. Losartan/hydrochlorothiazide - Wikipedia

    en.wikipedia.org/wiki/Losartan/hydrochlorothiazide

    Losartan/hydrochlorothiazide, sold under the brand name Hyzaar among others, is a fixed-dose combination medication used to treat high blood pressure when losartan is not sufficient. [1] [2] It consists of losartan, an angiotensin II receptor blocker; and hydrochlorothiazide, a thiazide diuretic. [1] [2] It is taken by mouth. [1] [2]

  6. Uricosuric - Wikipedia

    en.wikipedia.org/wiki/Uricosuric

    URAT1 is the central mediator in the transport of uric acid from the kidney into the blood. In some persons with loss-of-function mutations of URAT1, the uricosurics benzbromarone and losartan had no effect, suggesting these drugs act on URAT1 in vivo. [1] Thus, uricosuric drugs may be candidates for management in a personalized medicine model.

  7. Doctors Say This Nighttime Behavior Can Be A Sign Of Dementia

    www.aol.com/doctors-nighttime-behavior-sign...

    Sundowning also tends to happen consistently around the same time of day, Elhelou says. “It often includes cognitive effects such as significant disorientation or impaired judgement,” she says.

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  9. Valsartan - Wikipedia

    en.wikipedia.org/wiki/Valsartan

    Other serious side effects may include kidney problems, low blood pressure, and angioedema. [8] Use in pregnancy may harm the baby and use when breastfeeding is not recommended. [9] It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II. [8] Valsartan was patented in 1990, and came into medical use in ...

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