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The double-helix model of DNA structure was first published in the journal Nature by James Watson and Francis Crick in 1953, [6] (X,Y,Z coordinates in 1954 [7]) based on the work of Rosalind Franklin and her student Raymond Gosling, who took the crucial X-ray diffraction image of DNA labeled as "Photo 51", [8] [9] and Maurice Wilkins, Alexander Stokes, and Herbert Wilson, [10] and base-pairing ...
The DNA double helix was discovered in 1953 [4] (with further details in 1954 [5]) based on X-ray diffraction images of DNA (most notably photo 51, taken by Raymond Gosling and Rosalind Franklin [6]) as well as base-pairing chemical and biochemical information.
The chemical structure of DNA is insufficient to understand the complexity of the 3D structures of DNA. In contrast, animated molecular models allow one to visually explore the three-dimensional (3D) structure of DNA. The DNA model shown (far right) is a space-filling, or CPK, model of the DNA double helix. Animated molecular models, such as ...
The double helix is an important tertiary structure in nucleic acid molecules which is intimately connected with the molecule's secondary structure. A double helix is formed by regions of many consecutive base pairs. The nucleic acid double helix is a spiral polymer, usually right-handed, containing two nucleotide strands which base pair together.
The nucleosome is the basic unit of DNA condensation and consists of a DNA double helix bound to an octamer of core histones (2 dimers of H2A and H2B, and an H3/H4 tetramer). About 147 base pairs of DNA coil around 1 octamer, and ~20 base pairs are sequestered by the addition of the linker histone (H1), and various length of "linker" DNA (~0 ...
The Path to The Double Helix: Discovery of DNA. MacMillan. ISBN 978-0-486-68117-7. (with foreword by Francis Crick; revised in 1994, with a 9-page postscript.) Watson, James D. (1980). The Double Helix: A Personal Account of the Discovery of the Structure of DNA. Atheneum. ISBN 978-0-689-70602-8. (first published in 1968) Wilkins, Maurice (2003).
The tertiary arrangement of DNA's double helix in space includes B-DNA, A-DNA, and Z-DNA. Triple-stranded DNA structures have been demonstrated in repetitive polypurine:polypyrimidine Microsatellite sequences and Satellite DNA. B-DNA is the most common form of DNA in vivo and is a more narrow, elongated helix than A-DNA. Its wide major groove ...
The double helix is the dominant tertiary structure for biological DNA, and is also a possible structure for RNA. Three DNA conformations are believed to be found in nature, A-DNA, B-DNA, and Z-DNA. The "B" form described by James D. Watson and Francis Crick is believed to predominate in cells. [2]