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  2. Plague of Justinian - Wikipedia

    en.wikipedia.org/wiki/Plague_of_Justinian

    (photo from 1975 plague victim) A map of the Byzantine Empire in 550 (a decade after the Plague of Justinian) with Justinian's conquests shown in green The plague of Justinian or Justinianic plague (AD 541–549) was an epidemic that afflicted the entire Mediterranean Basin, Europe, and the Near East, severely affecting the Sasanian Empire and ...

  3. List of epidemics and pandemics - Wikipedia

    en.wikipedia.org/wiki/List_of_epidemics_and...

    Plague of Justinian: Bubonic plague 15–100 million 25–60% of European population [5] 541–549 North Africa, Europe, and Western Asia 3 HIV/AIDS pandemic: HIV/AIDS: 44 million (as of 2025) [a] 1981–present [6] Worldwide 4 Black Death: Bubonic plague: 25–50 million 30–60% of European population [7] 1346–1353 Europe, Asia, and North ...

  4. History of plague - Wikipedia

    en.wikipedia.org/wiki/History_of_plague

    The Plague of Justinian in AD 541–542 is the first known attack on record, and marks the first firmly recorded pattern of bubonic plague. This disease is thought to have originated in China. [ 19 ] It then spread to Africa from where the huge city of Constantinople imported massive amounts of grain, mostly from Egypt, to feed its citizens.

  5. When the skies went dark: Historians pinpoint the very 'worst ...

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    Dubbed the Justinian Pandemic or the Plague of Justinian, the disease spread throughout Roman Egypt before infecting the rest of the world over the ensuing 200 years.

  6. Plague is among the deadliest bacterial infections in human ...

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    Plague, one of the deadliest bacterial infections in human history, caused an estimated 50 million deaths in Europe during the Middle Ages when it was known as the Black Death.

  7. Consequences of the Black Death - Wikipedia

    en.wikipedia.org/wiki/Consequences_of_the_Black...

    Often simply referred to as "The Plague", the Black Death had both immediate and long-term effects on human population across the world as one of the most devastating pandemics in human history, including a series of biological, social, economic, political and religious upheavals that had profound effects on the course of world history ...

  8. What can the Black Death tell us about the global economic ...

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  9. Population of the Byzantine Empire - Wikipedia

    en.wikipedia.org/wiki/Population_of_the...

    It fluctuated throughout the state's millennial history. The reign of the Emperor Justinian I in the mid-sixth century was the high point of the empire's expansion; [1] however, the arrival of plague in 541 AD and its subsequent recurrences caused a severe depletion of the population. [2] After the reign of Emperor Heraclius (r.