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These have shown promise in treating refractory depression but come with serious side effects. [25] Among studies studies meeting the Cochrane 2019 inclusion criteria, two report that quetiapine augmentation does not improve overall quality of life. [17] One study on the 5-HT 1A receptor partial agonist buspirone met the Cochrane 2019 inclusion ...
The definition of refractory shock or vasodilatory shock varies. In 2018, the American College of Chest Physician stated that it is presents if there is an inadequate response to high-dose vasopressor therapy defined as ≥ 0.5 mg/kg/min norepinephrine-equivalent dose. [4]
[2] [5] It is a type of new-onset refractory status epilepticus (NORSE). [5] The seizures are often resistant to treatment. [2] High doses of benzodiazepines or barbiturates are often used, with care taking place in the intensive care unit. [2] A ketogenic diet may help in some cases. [1] The medications anakinra or tocilizumab have been tried. [2]
Drug-resistant epilepsy (DRE), also known as refractory epilepsy, intractable epilepsy, or pharmacoresistant epilepsy refers to a state in which an individual with a diagnosis of epilepsy is unresponsive to multiple first line therapies.
Refractory disease A refractory disease is a disease that resists treatment, especially an individual case that resists treatment more than is normal for the specific disease in question. Subclinical disease Also called silent disease, silent stage, or asymptomatic disease. This is a stage in some diseases before the symptoms are first noted. [23]
Refractory status epilepticus is defined as status epilepticus that continues despite treatment with benzodiazepines and one antiepileptic drug. [ 9 ] Super-refractory status epilepticus is defined as status epilepticus that continues or recurs 24 hours or more after the onset of anaesthetic therapy, including those cases where status ...
Shock is the state of insufficient blood flow to the tissues of the body as a result of problems with the circulatory system.Initial symptoms of shock may include weakness, tachycardia, hyperventilation, sweating, anxiety, and increased thirst. [1]
Palliative sedation is the use of sedative medications to relieve refractory symptoms when all other interventions have failed. The phrase "terminal sedation" was initially used to describe the practice of sedation at end of life, but was changed due to ambiguity as to what the word 'terminal' meant.