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A low serum osmolality will suppress the release of ADH, resulting in decreased water reabsorption and more concentrated plasma. Syndrome of inappropriate ADH secretion occurs when excessive release of antidiuretic hormone results in inappropriately elevated urine osmolality (>100 mOsmol/L) relative to the blood plasma, leading to hyponatraemia.
Causes of an elevated osmol gap are numerous. Generally there are 4 main causes: alcohols; sugars; lipids; proteins; All four are osmotically active substances found in humans. Accordingly, intoxications as listed below are reasons for an increased osmolar gap. Alcohols ethanol intoxication; methanol ingestion; ethylene glycol ingestion [9 ...
A relative insulin deficiency leads to a serum glucose that is usually higher than 33 mmol/L (600 mg/dL), and a resulting serum osmolarity that is greater than 320 mOsm. This leads to excessive urination (more specifically an osmotic diuresis ), which, in turn, leads to volume depletion and hemoconcentration that causes a further increase in ...
Normal volume hypernatremia can be due to fever, extreme thirst, prolonged increased breath rate, diabetes insipidus, and from lithium among other causes. [1] High volume hypernatremia can be due to hyperaldosteronism , excessive administration of intravenous normal saline or sodium bicarbonate , or rarely from eating too much salt .
Untreated central diabetes insipidus patients usually exhibit polyuria, nocturia, and polydipsia as a result of the initial rise of serum sodium and osmolality. [5] Patients may also experience neurologic symptoms associated with the underlying illness, such as headaches and diplopia, depending on the exact origin of the central diabetes insipidus.
Hyperosmolar syndrome or diabetic hyperosmolar syndrome is a medical emergency caused by a very high blood glucose level. The prefix "hyper-" means high, and "osmolarity" is a measure of the concentration of active particles in a solution, so the name of the syndrome simply refers to the high concentration of glucose in the blood.
High anion gap metabolic acidosis is a form of metabolic acidosis characterized by a high anion gap (a medical value based on the concentrations of ions in a patient's serum). Metabolic acidosis occurs when the body produces too much acid , or when the kidneys are not removing enough acid from the body.
For salts, electrostatic effects cause φ to be smaller than 1 even if 100% dissociation occurs (see Debye–Hückel equation); n is the number of particles (e.g. ions) into which a molecule dissociates. For example: glucose has n of 1, while NaCl has n of 2; C is the molar concentration of the solute;
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