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Wistar rat. The Wistar rat is an outbred albino rat. This breed was developed at the Wistar Institute in 1906 for use in biological and medical research, and is notably the first rat developed to serve as a model organism at a time when laboratories primarily used the house mouse (Mus musculus).
Caspar Wistar (1761–1818), physician and anatomist, grandson of the glassmaker. Isaac J. Wistar (1827-1905), Union general and penologist. Wistar Institute, a biomedical research center in Philadelphia, Pennsylvania, named after the physician. Wistar rat, a strain of albino laboratory rats developed at the institute.
Rodents such as rats are the most common model in researching effects of cardiovascular disease, as the effects on rodents mimic those in humans. [12] Rats have also been used as tools in research to try to find if there is a difference in the effects of cocaine on adults versus adolescents. [13]
Sprague Dawley rat; W. Wistar rat; Z. ZDF rat; Zucker diabetic fatty rat; Zucker rat This page was last edited on 12 October 2015, at 22:02 (UTC). Text is available ...
Rats are also associated with human dermatitis because they are frequently infested with blood feeding rodent mites such as the tropical rat mite (Ornithonyssus bacoti) and spiny rat mite (Laelaps echidnina), which will opportunistically bite and feed on humans, [57] where the condition is known as rat mite dermatitis.
"The period before World War I led to the initiation of inbreeding in rats by Dr Helen King in about 1909 and in mice by Dr C. C. Little in 1909. The latter project led to the development of the DBA strain of mice, now widely distributed as the two major sub-strains DBA/1 and DBA/2, which were separated in 1929-1930.
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Examples include the BALB/c mouse and Wistar and Sprague Dawley rat strains, laboratory rabbits and ferrets. [39] Some researchers have argued that albino animals are not always the best choice for scientific studies due to the consequences of albinism (e.g. hearing and visual impairments). [40]